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Mostrando ítems 131-140 de 171
Artículo
Prolonged quiescence delays somatic stem cell-like divisions in Caenorhabditis elegans and is controlled by insulin signaling
(Wiley Open Access, 2020)
Cells can enter quiescence in adverse conditions and resume proliferation when the environment becomes favorable. Prolonged quiescence comes with a cost, reducing the subsequent speed and potential to return to proliferation. ...
Tesis Doctoral
Design of biological sensors based on the OpvAB phase variation system of Salmonella enterica
(2020-02-21)
Este trabajo se ha basado en investigaciones previas de nuestro grupo sobre el operón opvAB de Salmonella enterica y ha utilizado dichos conocimientos para diseñar y desarrollar tres aplicaciones biotecnológicas: (i) la ...
Artículo
Cell consequences of loss of function of the epigenetic factor EHMT1
(Elsevier, 2023)
EHMT1 is an epigenetic factor with histone methyltransferase activity that appears mutated in Kleefstra syndrome, a neurodevelopmental genetic disorder characterized by developmental delay, intellectual disability, and ...
Artículo
Survey of Early-Diverging Lineages of Fungi Reveals Abundant and Diverse Mycoviruses
(American Society for Microbiology, 2020)
Mycoviruses are widespread and purportedly common throughout the fungal kingdom, although most are known from hosts in the two most recently diverged phyla, Ascomycota and Basidiomycota, together called Dikarya. To augment ...
Artículo
The human nucleoporin Tpr protects cells from RNA-mediated replication stress
(Springer Nature, 2021)
Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr depletion generates transcription-dependent replication stress, DNA breaks, and genomic instability. ...
Tesis Doctoral
Molecular bases of proliferative heterogeneity in Saccharomyces cerevisiae
(2023-05-11)
Proliferative heterogeneity has been widely described in clonal cultures, but the mechanisms underlying this phenomenon are still poorly understood. On another hand, cell cycle regulation is tightly linked to proliferative ...
Artículo
A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability
(Genetics Society of America, 2022)
The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be influenced by the chromatin context. This is mainly due to the fact that DNA-RNA hybrids hamper the ...
Artículo
Waddington's Landscapes in the Bacterial World
(Frontiers Media, 2021)
Conrad Waddington's epigenetic landscape, a visual metaphor for the development of multicellular organisms, is appropriate to depict the formation of phenotypic variants of bacterial cells. Examples of bacterial differentiation ...
Artículo
The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation
(Taylor & Francis, 2022)
The small ribosomal subunit protein Rps15/uS19 is involved in early nucleolar ribosome biogenesis and subsequent nuclear export of pre-40S particles to the cytoplasm. In addition, the C-terminal tail of Rps15 was suggested ...
Artículo
WHI-2 Regulates Intercellular Communication via a MAP Kinase Signaling Complex
(Frontiers Media, 2020)
he formation of the fungal mycelial network is facilitated by somatic cell fusion of germinating asexual spores (or germlings). Neurospora crassa germlings in close proximity display chemotropic growth that is dependent ...