dc.creator | Zambrano Vega, Cristian | es |
dc.creator | Nebro, Antonio J. | es |
dc.creator | García Nieto, José Manuel | es |
dc.creator | Aldana Montes, José F. | es |
dc.date.accessioned | 2021-05-10T10:50:06Z | |
dc.date.available | 2021-05-10T10:50:06Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Zambrano Vega, C., Nebro, A.J., García Nieto, J.M. y Aldana Montes, J.F. (2017). M2Align: parallel multiple sequence alignment with a multi-objective metaheuristic. Bioinformatics, 33 (19), 3011-3017. | |
dc.identifier.issn | 1367-4803 | es |
dc.identifier.uri | https://hdl.handle.net/11441/108772 | |
dc.description.abstract | Motivation: Multiple sequence alignment (MSA) is an NP-complete optimization problem found in computational
biology, where the time complexity of finding an optimal alignment raises exponen-tially along with the number of
sequences and their lengths. Additionally, to assess the quality of a MSA, a number of objectives can be taken into
account, such as maximizing the sum-of-pairs, maximizing the totally conserved columns, minimizing the number of
gaps, or maximizing struc-tural information based scores such as STRIKE. An approach to deal with MSA problems
is to use multi-objective metaheuristics, which are non-exact stochastic optimization methods that can pro-duce high
quality solutions to complex problems having two or more objectives to be optimized at the same time. Our
motivation is to provide a multi-objective metaheuristic for MSA that can run in parallel taking advantage of multicore-
based computers.
Results: The software tool we propose, called M2Align (Multi-objective Multiple Sequence Alignment), is a parallel
and more efficient version of the three-objective optimizer for sequence alignments MO-SAStrE, able of reducing the
algorithm computing time by exploiting the comput-ing capabilities of common multi-core CPU clusters. Our
performance evaluation over datasets of the benchmark BAliBASE (v3.0) shows that significant time reductions can
be achieved by using up to 20 cores. Even in sequential executions, M2Align is faster than MO-SAStrE, thanks to
the encod-ing method used for the alignments.
Availability and implementation: M2Align is an open source project hosted in GitHub, where the source code
and sample datasets can be freely obtained: https://github.com/KhaosResearch/M2Align. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad TIN2014-58304-R | es |
dc.description.sponsorship | Junta de Andalucía P11-TIC-7529 | es |
dc.description.sponsorship | Junta de Andalucía P12-TIC-1519 | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language.iso | eng | es |
dc.publisher | Oxford University Press | es |
dc.relation.ispartof | Bioinformatics, 33 (19), 3011-3017. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | M2Align: parallel multiple sequence alignment with a multi-objective metaheuristic | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/submittedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial | es |
dc.relation.projectID | TIN2014-58304-R | es |
dc.relation.projectID | P11-TIC-7529 | es |
dc.relation.projectID | P12- TIC-1519 | es |
dc.relation.publisherversion | https://academic.oup.com/bioinformatics/article/33/19/3011/3852082 | es |
dc.identifier.doi | 10.1093/bioinformatics/btx338 | es |
dc.journaltitle | Bioinformatics | es |
dc.publication.volumen | 33 | es |
dc.publication.issue | 19 | es |
dc.publication.initialPage | 3011 | es |
dc.publication.endPage | 3017 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |
dc.contributor.funder | Junta de Andalucía | es |