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Mostrando ítems 11-20 de 31
Artículo
A Single Zinc Finger Motif in the Silencing Factor Rest Represses the Neural-Specific Type II Sodium Channel Promoter.
(PNAS, 1997)
The type II voltage-dependent sodium chan- nel is present in neuronal cells, where it mediates the prop- agationofnerveimpulses.RestrictedexpressionofthetypeII sodium channel gene to neurons is due, at least in part, ...
Artículo
Regulation of Dab2 expression in intestinal and renal epithelia by development
(Wiley-Blackwell, 2011)
Disabled-2 (Dab2) is an intracellular adaptor protein proposed to function in endocytosis. Here, we investigate the intestinal and renal Dab2 expression versus maturation. Dab2 mRNA levels measured by RT-PCR are greater ...
Artículo
Reelin Protects against Colon Pathology via p53 and May Be a Biomarker for Colon Cancer Progression
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Previous observations made in human and mouse colons suggest that reelin protects the colon from pathology. In this study, we evaluated reelin expression during the transition from either colitis or precancerous lesions ...
Artículo
Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain
(Wiley, 2024-01-16)
Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether ...
Artículo
Reelin protects from colon pathology by maintaining the intestinal barrier integrity and repressing tumorigenic genes
(Elsevier, 2017)
We previously reported that reelin, an extracellular matrix protein first known for its key role in neuronal migration, reduces the susceptibility to dextran sulphate sodium (DSS)-colitis. The aim of the current study was ...
Artículo
Small and large intestine express a truncated Dab1 isoform that assembles in cell-cell junctions and co-localizes with proteins involved in endocytosis
(Elsevier, 2018)
Disabled-1 (Dab1) is an essential intracellular adaptor protein in the reelin pathway. Our previous studies in mice intestine showed that Dab1 transmits the reelin signal to cytosolic signalling pathways. Here, we determine ...
Artículo
Na+-dependent D-mannose transport at the apical membrane of rat small intestine and kidney cortex
(Elsevier, 2001)
The presence of a Na+/D-mannose cotransport activity in brush-border membrane vesicles (BBMV), isolated from either rat small intestine or rat kidney cortex, is examined. In the presence of an electrochemical Na+ gradient, ...
Tesis Doctoral
El sistema de señalización de la reelina en la homeostasis y en la inflamación del colon
(2016-07-18)
En 1951, Falconer describió por primera vez un tipo de ratones mutantes espontáneos a los que denominó reeler, los cuales presentaban una mutación autosómica recesiva que les provocaba anormalidades arquitectónicas severas ...
Artículo
Dab1 and reelin participate in a common signal pathway that controls intestinal crypt/villus unit dynamics
(Wiley-Blackwell, 2014)
Background information: The myofibroblasts placed underneath the epithelium of the rodent small intestine express reelin, and the reelin absence modifies both the morphology and the cell renewal processes of the crypt-villus ...
Artículo
Hormonal Regulation of chicken intestinal NHE and SGLT-1 activities
(2001)
The effects of aldosterone and arginine vasotocin (AVT) on intestinal Na/Hexchange (NHE) and Na-sugar cotransport (SGLT-1) activi-ties have been investigated using brush-border membrane ves-icles isolated from Hubbard ...