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Artículo
Functional Diversity of Neurotrophin Actions on the Oculomotor System
(MDPI AG, 2016)
Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes. In the oculomotor system, we have demonstrated ...
Artículo
Vascular Endothelial Growth Factor (VEGF) Prevents the Downregulation of the Cholinergic Phenotype in Axotomized Motoneurons of the Adult Rat
(Frontiers Media, 2018)
Vascular endothelial growth factor (VEGF) was initially characterized by its activity on the vascular system. However, there is growing evidence indicating that VEGF also acts as a neuroprotective factor, and that its ...
Artículo
VEGF and Neuronal Survival
(SAGE, 2022)
Vascular endothelial growth factor (VEGF) is well known for its angiogenic activity, but recent evidence has revealed a neuroprotective action of this factor on injured or diseased neurons. In the present review, we summarize ...
Artículo
Role of Vascular Endothelial Growth Factor as a Critical Neurotrophic Factor for the Survival and Physiology of Motoneurons
(Wolters Kluwer Health, 2023)
Vascular endothelial growth factor (VEGF) was discovered by its angiogenic activity. However, during evolution, it appeared earlier as a neurotrophic factor required for the development of the nervous system in invertebrates ...
Artículo
Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF
(Springer Nature, 2023)
The potassium chloride cotransporter 2 (KCC2) is the main Cl− extruder in neurons. Any alteration in KCC2 levels leads to changes in Cl− homeostasis and, consequently, in the polarity and amplitude of inhibitory synaptic ...
Artículo
Relative contribution of lateral vestibular neuron and abducens internuclear neuron inputs to the discharge activity of medial rectus motoneurons
(Springer, 2023)
Medial rectus motoneurons mediate nasally directed horizontal eye movements. These motoneurons receive two major excitatory inputs, from the abducens internuclear neurons (ABD Ints) and neurons of the lateral vestibular ...
Artículo
Eye Movements But Not Vision Drive the Development of Palisade Endings
(Association for Research in Vision and Ophthalmology, 2022)
PURPOSE. To test whether visual experience and/or eye movements drive the postnatal development of palisade endings in extraocular muscles. METHODS. In three newborn cats, the right eye was covered until 30 days from ...
Artículo
VEGF is an essential retrograde trophic factor for motoneurons
(National Academy of Sciences, 2022)
VEGF was initially discovered due to its angiogenic activity and therefore named "vascular endothelial growth factor."However, its more recently discovered neurotrophic activity may be evolutionarily more ancient. Our ...
Artículo
Proprioceptors in extraocular muscles
(Wiley-Blackwell, 2023)
New Findings: What is the topic of this review? This review aims to evaluate the literature on proprioceptors and particular nerve specializations (palisade endings) in mammalian extraocular muscles (EOMs) and to reconsider ...
Artículo
Implanted neural progenitor cells regulate glial reaction to brain injury and establish gap junctions with host glial cells
(Wiley-Blackwell, 2014)
Transplantation of neural stem/progenitor cells (NPCs) in the lesioned brain is able to restore morphological and physiological alterations induced by different injuries. The local microenvironment created at the site of ...