Search
Now showing items 1-7 of 7
Article
Functional Diversity of Neurotrophin Actions on the Oculomotor System
(MDPI AG, 2016)
Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes. In the oculomotor system, we have demonstrated ...
Article
VEGF and Neuronal Survival
(SAGE, 2022)
Vascular endothelial growth factor (VEGF) is well known for its angiogenic activity, but recent evidence has revealed a neuroprotective action of this factor on injured or diseased neurons. In the present review, we summarize ...
Article
Sources and lesion-induced changes of VEGF expression in brainstem motoneurons
(Springer Nature, 2020-04-01)
Motoneurons of the oculomotor system show lesser vulnerability to neurodegeneration compared to other cranial motoneurons, as seen in amyotrophic lateral sclerosis (ALS). The overexpression of vascular endothelial growth ...
Article
VEGF is an essential retrograde trophic factor for motoneurons
(National Academy of Sciences, 2022)
VEGF was initially discovered due to its angiogenic activity and therefore named "vascular endothelial growth factor."However, its more recently discovered neurotrophic activity may be evolutionarily more ancient. Our ...
Article
Complementary Actions of BDNF and Neurotrophin-3 on the Firing Patterns and Synaptic Composition of Motoneurons
(Society for Neuroscience, 2009)
Neurotrophins, as target-derived factors, are essential for neuronal survival during development, but during adulthood, their scope of actions widens to become also mediators of synaptic and morphological plasticity. Target ...
Article
Synaptic loss and firing alterations in Axotomized Motoneurons are restored by vascular endothelial growth factor (VEGF) and VEGF-B
(Elsevier, 2018)
Vascular endothelial growth factor (VEGF), also known as VEGF-A, was discovered due to its vasculogenic and angiogenic activity, but a neuroprotective role for VEGF was later proven for lesions and disorders. In different ...
Article
Implanted neural progenitor cells regulate glial reaction to brain injury and establish gap junctions with host glial cells
(Wiley-Blackwell, 2014)
Transplantation of neural stem/progenitor cells (NPCs) in the lesioned brain is able to restore morphological and physiological alterations induced by different injuries. The local microenvironment created at the site of ...