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Artículo
VEGF expression disparities in brainstem motor neurons of the SOD1GP3A ALS model: Correlations with neuronal vulnerability
(Elsevier, 2024)
Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease characterized by severe muscle weakness mainly due to degeneration and death of motor neurons. A peculiarity of the neurodegenerative processes is ...
Artículo
Functional Diversity of Neurotrophin Actions on the Oculomotor System
(MDPI AG, 2016)
Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes. In the oculomotor system, we have demonstrated ...
Artículo
The Use of PRV-Bartha to Define Premotor Inputs to Lumbar Motoneurons in the Neonatal Spinal Cord of the Mouse
(Public Library of Science, 2010)
Background The neonatal mouse has become a model system for studying the locomotor function of the lumbar spinal cord. However, information about the synaptic connectivity within the governing neural network remains ...
Artículo
Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles
(MDPI, 2020)
Extraocular muscles (EOMs) show resistance to muscle dystrophies and sarcopenia. It has been recently demonstrated that they are endowed with different types of myogenic cells, all of which present an outstanding regenerative ...
Tesis Doctoral
Dependencias tróficas y sinápticas del sistema oculomotor.
(2018-02-23)
Las motoneuronas del recto medial presentes en el núcleo motor ocular común (NMOC) reciben dos entradas pontinas principales: las neuronas internucleares del núcleo motor ocular externo (NMOE), cuyos axones discurren por ...
Patente. Invención
Discriminador de formas de potenciales de acción
(Oficina Española de Patentes y Marcas (OEPM), 1998-01-16)
Discriminador de formas de potenciales de acción, que permite seleccionar, dentro de un tren de potenciales de acción o espigas, aquellos que posean una amplitud o forma que esté dentro de unos limites establecidos, ...
Tesis Doctoral
Implante de progenitores neurales en un modelo de lesión del sistema oculomotor
(2015-11-11)
El implante de células progenitoras neurales en el sistema nervioso central lesionado es una poderosa herramienta reparadora. Sin embargo, aún no se han evaluado extensamente los efectos de dichos implantes sobre el patrón ...
Artículo
Vascular Endothelial Growth Factor (VEGF) Prevents the Downregulation of the Cholinergic Phenotype in Axotomized Motoneurons of the Adult Rat
(Frontiers Media, 2018)
Vascular endothelial growth factor (VEGF) was initially characterized by its activity on the vascular system. However, there is growing evidence indicating that VEGF also acts as a neuroprotective factor, and that its ...
Artículo
Extracellular Vesicle-Mediated Communication between the Glioblastoma and Its Microenvironment
(MDPI, 2019)
The glioblastoma is the most malignant form of brain cancer. Glioblastoma cells use multiple ways of communication with the tumor microenvironment in order to tune it for their own benefit. Among these, extracellular ...
Artículo
Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells
(Frontiers Media, 2023)
The subventricular zone (SVZ) is a brain region that contains neural stem cells and progenitor cells (NSCs/NPCs) from which new neurons and glial cells are formed during adulthood in mammals. Recent data indicate that ...