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Artículo
Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain
(Wiley, 2024-01-16)
Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether ...
Artículo
Effects of classical PKC activation on hippocampal neurogenesis and cognitive performance: mechanism of action
(Springer Nature, 2021)
Hippocampal neurogenesis has widely been linked to memory and learning performance. New neurons generated from neural stem cells (NSC) within the dentate gyrus of the hippocampus (DG) integrate in hippocampal circuitry ...
Artículo
Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Neurodegenerative diseases are characterized by gradually progressive, selective loss of anatomically or physiologically related neuronal systems that produce brain damage from which there is no recovery. Despite the ...
Artículo
Age-Dependent Vulnerability to Oxidative Stress of Postnatal Rat Pyramidal Motor Cortex Neurons
(MDPI, 2020-12)
Oxidative stress is one of the main proposed mechanisms involved in neuronal degeneration. To evaluate the consequences of oxidative stress on motor cortex pyramidal neurons during postnatal development, rats were ...
Artículo
Microbiota-liver-bile salts axis, a novel mechanism involved in the contrasting effects of sodium selenite and selenium-nanoparticle supplementation on adipose tissue development in adolescent rats
(MDPI, 2023)
Adolescence is a period during which body composition changes deeply. Selenium (Se) is an excellent antioxidant trace element related to cell growth and endocrine function. In adolescent rats, low Se supplementation affects ...
Artículo
Different effects of low selenite and selenium-nanoparticle supplementation on adipose tissue function and insulin secretion in adolescent male rats
(MDPI, 2022)
Adolescence is a period of intense growth and endocrine changes, and obesity and insulin-resistance processes during this period have lately been rising. Selenium (Se) homeostasis is related to lipid metabolism depending ...