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Protein Quality Control Systems and ER Stress as Key Players in SARS-CoV-2-Induced Neurodegeneration
(MDPI, 2024-01-09)
The COVID-19 pandemic has brought to the forefront the intricate relationship between SARS-CoV-2 and its impact on neurological complications, including potential links to neurodegenerative processes, characterized by a ...
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Genomic responses to arsenic in the cyanobacterium Synechocystis sp. PCC 6803
(Public Library of Science, 2014)
Arsenic is a ubiquitous contaminant and a toxic metalloid which presents two main redox states in nature: arsenite [AsIII] and arsenate [AsV]. Arsenic resistance in Synechocystis sp. strain PCC 6803 is mediated by the ...
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Dynamics of the Intrinsically Disordered Inhibitor IF7 of Glutamine Synthetase in Isolation and in Complex with its Partner
(Elsevier, 2020)
Glutamine synthetase (GS) catalyzes the ATP-dependent formation of glutamine from glutamate and ammonia. The activity of Synechocystis sp. PCC 6803 GS is regulated, among other mechanisms, by protein-protein interactions ...
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Functional dependence between septal protein SepJ from Anabaena sp. Strain PCC 7120 and an amino acid ABC-type uptake transporter
(American Society for Microbiology, 2015)
In the diazotrophic filaments of heterocyst-forming cyanobacteria, two different cell types, the CO2-fixing vegetative cells and the N2-fixing heterocysts, exchange nutrients, including some amino acids. In the model ...
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MipZ caps the plus-end of FtsZ polymers to promote their rapid disassembly
(NAS, 2022-12-09)
The spatiotemporal regulation of cell division is a fundamental issue in cell biology. Bacteria have evolved a variety of different systems to achieve proper division site placement. In many cases, the underlying molecular ...
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Alr0397 is an outer membrane transporter for the siderophore schizokinen in Anabaena sp. strain PCC 7120
(American Society for Microbiology, 2008)
Iron uptake in proteobacteria by TonB-dependent outer membrane transporters represents a well-explored subject. In contrast, the same process has been scarcely investigated in cyanobacteria. The heterocyst-forming ...
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Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative
(Frontiers Media, 2018)
Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative diseases. In some of these pathologies, such as Amyotrophic Lateral Sclerosis or Multiple Sclerosis, ...