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Mostrando ítems 1-5 de 5
Artículo
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
(American Society for Clinical Investigation, 2022)
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the ...
Artículo
Determination of the lipid composition of the GPI anchor
(PLOS, 2021)
In eukaryotic cells, a subset of cell surface proteins is attached by the glycolipid glycosylphosphatidylinositol (GPI) to the external leaflet of the plasma membrane where they play important roles as enzymes, receptors, ...
Artículo
A Role for Lipids in Protein Sorting?
(Swiss Chemical Society, 2021)
Lipid and protein diversity provides structural and functional identity to the membrane compartments that define the eukaryotic cell. This compositional heterogeneity is maintained by the secretory pathway, which feeds ...
Artículo
Structural analysis of the GPI glycan
(PLOS, 2021)
Glycosylphosphatidylinositol (GPI) anchoring of proteins is an essential post-translational modification in all eukaryotes that occurs at the endoplasmic reticulum (ER) and serves to deliver GPI-anchored proteins (GPI-APs) ...
Artículo
Loss of GATA4 causes ectopic pancreas in the stomach
(John Wiley & Sons, 2020-04)
Pancreatic heterotopia is defined as pancreatic tissue outside its normal location in the body and anatomically separated from the pancreas. In this work we have analyzed the stomach glandular epithelium of Gata4flox/flox; ...