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Artículo
XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
(Springer Nature, 2022)
Cells employ global genome nucleotide excision repair (GGR) to eliminate a broad spectrum of DNA lesions, including those induced by UV light. The lesion-recognition factor XPC initiates repair of helix-destabilizing DNA ...
Artículo
SUMO-activated Target Traps (SATTs) Enable the Identification of a Comprehensive E3-specific SUMO Proteome
(American Association for the Advancement of Science, 2023)
Ubiquitin and ubiquitin-like conjugation cascades consist of dedicated E1, E2, and E3 enzymes with E3s providing substrate specificity. Mass spectrometry–based approaches have enabled the identification of more than 6500 ...
Artículo
A disease-associated XPA Allele Interferes with TFIIH Binding and Primarily Affects Transcription-coupled Nucleotide Excision Repair
(National Academy of Sciences, 2023)
XPA is a central scaffold protein that coordinates the assembly of repair complexes in the global genome (GG-NER) and transcription-coupled nucleotide excision repair (TC-NER) subpathways. Inactivating mutations in XPA ...
Artículo
Curvature in Biological Systems: Its Quantification, Emergence, and Implications across the Scales
(John Wiley and Sons Inc, 2023-03-29)
Surface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell membranes to single cells to tissues and organs. The relevance of surface curvature in biology is ...
Artículo
Repeat RNAs associate with replication forks and post-replicative DNA
(Cold Spring Harbor Laboratory Press, 2020)
Noncoding RNA has a proven ability to direct and regulate chromatin modifications by acting as scaffolds between DNA and histone-modifying complexes. However, it is unknown if ncRNA plays any role inDNAreplication and ...