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Artículo
XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
(Springer Nature, 2022)
Cells employ global genome nucleotide excision repair (GGR) to eliminate a broad spectrum of DNA lesions, including those induced by UV light. The lesion-recognition factor XPC initiates repair of helix-destabilizing DNA ...
Artículo
A disease-associated XPA Allele Interferes with TFIIH Binding and Primarily Affects Transcription-coupled Nucleotide Excision Repair
(National Academy of Sciences, 2023)
XPA is a central scaffold protein that coordinates the assembly of repair complexes in the global genome (GG-NER) and transcription-coupled nucleotide excision repair (TC-NER) subpathways. Inactivating mutations in XPA ...