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Mostrando ítems 11-20 de 29
Tesis Doctoral
Estudio de la arquitectura epitelial en 3D, su variación natural y la aparición de patrones morfológicos a nivel celular
(2023-07-11)
Una de las cuestiones más fascinantes de la Biología del desarrollo es entender cómo los tejidos y órganos adquieren su forma, crítica para su función, en un proceso que se denomina morfogénesis. La fiel ejecución del ...
Artículo
Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy
(Nature Publishing Group, 2018)
Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis ...
Artículo
Author Correction: Scutoids are a geometrical solution to three-dimensional packing of epithelia
(Nature Research, 2018)
Tesis Doctoral
Scutoids unveil the three-dimensional packing in curved epithelia
(2020-07-16)
As animals develop, the initial simple planar epithelia of the early embryos must acquire complex three-dimensional architectures to form the final functional tissues of the organism. Epithelial bending is, therefore, a ...
Artículo
ATM specifically mediates repair of double-strand breaks with blocked DNA ends
(Nature Publishing Group, 2014)
Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator ...
Artículo
Mechanism of G1 arrest in the Drosophila eye imaginal disc
(2007)
Background: Most differentiating cells are arrested in G1-phase of the cell cycle and this proliferative quiescence appears important to allow differentiation programmes to be executed. An example occurs in the Drosophila ...
Artículo
Topological Progression in Proliferating Epithelia Is Driven by a Unique Variation in Polygon Distribution
(Public Library of Science, 2013)
Morphogenesis is consequence of lots of small coordinated variations that occur during development. In proliferating stages, tissue growth is coupled to changes in shape and organization. A number of studies have analyzed ...
Artículo
The topology of vitronectin: A complementary feature for neuroblastoma risk classification based on computer-aided detection
(Wiley, 2020)
Tumors are complex networks of constantly interacting elements: tumor cells, stromal cells, immune and stem cells, blood/lympathic vessels, nerve fibers and extracellular matrix components. These elements can influence ...
Tesis Doctoral
Topological analysis of the tumour microenvironment to study Neuroblastoma
(2020-09-03)
Solid tumours and their tumour microenvironment (TME) can be considered as complex networks whose elements are in constant physical stress. All the elements of the TME, including tumour cells, stromal cells, immune and ...
Artículo
Biotensegrity of the Extracellular Matrix: Physiology, Dynamic Mechanical Balance, and Implications in Oncology and Mechanotherapy
(Frontiers Media, 2014)
Cells have the capacity to convert mechanical stimuli into chemical changes. This process is based on the tensegrity principle, a mechanism of tensional integrity. To date, this principle has been demonstrated to act in ...