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Mostrando ítems 1-8 de 8
Artículo
EpiGraph: an open-source platform to quantify epithelial organization
(Oxford University Press, 2020)
Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational geometry and graph theory to measure the degree of order of any packed tissue. EpiGraph goes beyond ...
Artículo
The complex three-dimensional organization of epithelial tissues
(The Company of Biologists Ltd., 2021)
Understanding the cellular organization of tissues is key to developmental biology. In order to deal with this complex problem, researchers have taken advantage of reductionist approaches to reveal fundamental morphogenetic ...
Artículo
CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia
(Elsevier, 2023)
Decades of research have not yet fully explained the mechanisms of epithelial self-organization and 3D packing. Single-cell analysis of large 3D epithelial libraries is crucial for understanding the assembly and function ...
Artículo
Author Correction: Scutoids are a geometrical solution to three-dimensional packing of epithelia
(Nature Research, 2018)
Artículo
The topology of vitronectin: A complementary feature for neuroblastoma risk classification based on computer-aided detection
(Wiley, 2020)
Tumors are complex networks of constantly interacting elements: tumor cells, stromal cells, immune and stem cells, blood/lympathic vessels, nerve fibers and extracellular matrix components. These elements can influence ...
Tesis Doctoral
Topological analysis of the tumour microenvironment to study Neuroblastoma
(2020-09-03)
Solid tumours and their tumour microenvironment (TME) can be considered as complex networks whose elements are in constant physical stress. All the elements of the TME, including tumour cells, stromal cells, immune and ...
Artículo
A quantitative principle to understand 3D cellular connectivity in epithelial tubes
(Cell Systems, 2022)
Apico-basal cell intercalations (scutoids) optimize packing and energy expenditure in curved epithelia. Further consequences of this new paradigm of tissue packing remain uncharacterized. In particular, how scutoids modify ...
Artículo
Scutoids are a geometrical solution to three-dimensional packing of epithelia
(Nature Publishing Group, 2018)
As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of ...