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Browsing Biología Celular by Author "Salas Lloret, Daniel"
Now showing items 1-5 of 5
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Article
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis
Salas Lloret, Daniel; García Rodríguez, Néstor; Soto Hidalgo, Emily; González Vinceiro, Lourdes; Espejo Serrano, Carmen; Giebel, Lisanne; Huertas Sánchez, Pablo; González Prieto, Román (Nature Research, 2024-05-20)Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is ...
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Article
RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse
Condezo, Yazmine B.; Sáinz Urruela, Raquel; Gómez-H , Laura; Salas Lloret, Daniel; Felipe Medina, Natalia; Bradley, Rachel; González Prieto, Román; Llano, Elena (National Academy of Sciences, 2024-06-12)Meiosis, a reductional cell division, relies on precise initiation, maturation, and resolution of crossovers (COs) during ...
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Article
SUMO-activated Target Traps (SATTs) Enable the Identification of a Comprehensive E3-specific SUMO Proteome
Salas Lloret, Daniel; Jansen, Nicolette S.; Nagamalleswari, Easa; van der Meulen, Coen; Gracheva, Ekaterina; de Ru, Arnoud H.; Otte, H. Anne Marie; van Veelen, Peter A.; Pichler, Andrea; Goedhart, Joachim; Vertegaal, Alfred C.O.; González Prieto, Román (American Association for the Advancement of Science, 2023)Ubiquitin and ubiquitin-like conjugation cascades consist of dedicated E1, E2, and E3 enzymes with E3s providing substrate ...
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Article
UBE2D3 Facilitates NHEJ by Orchestrating ATM Signalling through Multi-level Control of RNF168
Yalçin, Zeliha; Lam, Shiu Yeung; Peuscher, Marieke H.; van der Torre, Jaco; Zhu, Sha; Iyengar, Prasanna V.; Salas Lloret, Daniel; de Krijger, Inge; Moatti, Nathalie; van der Lugt, Ruben; González Prieto, Román; Jacobs, Jacqueline J.L. (Springer Nature, 2024)Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation ...
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Article
Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control
Yalçin, Zeliha; Koot, Daniëlle; Bezstarosti, Karel; Salas Lloret, Daniel; Bleijerveld, Onno B.; Boersma, Vera; Falcone, Mattia; González Prieto, Román; Altelaar, Maarten; Demmers, Jeroen A.A.; Jacobs, Jacqueline J.L. (Elsevier, 2023)Ubiquitination has crucial roles in many cellular processes, and dysregulation of ubiquitin machinery enzymes can result ...