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dc.creatorSánchez González, José Maríaes
dc.creatorHita Cantalejo, María Concepción dees
dc.creatorSánchez González, María del Carmenes
dc.date.accessioned2021-04-16T15:56:47Z
dc.date.available2021-04-16T15:56:47Z
dc.date.issued2020
dc.identifier.citationSánchez González, J.M., Hita Cantalejo, M.C.d. y Sánchez González, M.C. (2020). Crosslinked hyaluronic acid with liposomes and crocin for management symptoms of dry eye disease caused by moderate meibomian gland dysfunction. International Journal of Ophthalmology, 13 (9), 1368-1373.
dc.identifier.issn2222-3959es
dc.identifier.issn2227-4898es
dc.identifier.urihttps://hdl.handle.net/11441/107255
dc.description.abstractAIM: To study the effect of uncrosslinked and crosslinked hyaluronic acid combined with other artificial tear components in patients with dry eye caused by moderate meibomian gland dysfunction. METHODS: Prospective, single-blind, contralateral eye study. Fifty eyes (25 patients) were analyzed. Eye selection for each tear type was random, and the eye drop formulations, 0.4% uncrosslinked hyaluronic acid and 0.2% galactoxyloglucan (tear A) and 0.15% crosslinked hyaluronic acid, crocin, and liposomes (tear B) were used. The determined dosing schedule was three times a day for six weeks, and the study participants underwent a clinical examination before and 45d after lubricant treatment. The Schirmer test, tear breakup time (TBUT) test, and Ocular Surface Disease Index (OSDI) questionnaire were applied before and after instillation period with both types of artificial tears. RESULTS: On the Schirmer test, a significant improvement was obtained with both tear A (P<0.01) and tear B (P<0.01). On the TBUT test, a significant improvement was obtained with tear A (P<0.01) and tear B (P<0.01). The OSDI score significantly decreased after instillation period with both artificial tear types (P<0.01). CONCLUSION: Uncrosslinked hyaluronic acid combined with other components, such as tamarind seed polysaccharide, and crosslinked hyaluronic acid combined with liposomes and crocin are effective for management symptoms of dry eye disease.es
dc.formatapplication/pdfes
dc.format.extent6 p.es
dc.language.isoenges
dc.publisherPress of International Journal of Ophthalmologyes
dc.relation.ispartofInternational Journal of Ophthalmology, 13 (9), 1368-1373.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectContact lenses
dc.subjectCrosslinked hyaluronic acides
dc.subjectDry eye diseasees
dc.subjectLiposomees
dc.subjectMeibomian gland dysfunctiones
dc.titleCrosslinked hyaluronic acid with liposomes and crocin for management symptoms of dry eye disease caused by moderate meibomian gland dysfunctiones
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Física de la Materia Condensadaes
dc.relation.publisherversionhttp://dx.doi.org/10.18240/ijo.2020.09.05es
dc.identifier.doi10.18240/ijo.2020.09.05es
dc.journaltitleInternational Journal of Ophthalmologyes
dc.publication.volumen13es
dc.publication.issue9es
dc.publication.initialPage1368es
dc.publication.endPage1373es

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