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Mostrando ítems 1-10 de 14
Artículo
Neurotoxic assessment of Microcystin-LR, cylindrospermopsin andtheir combination on the human neuroblastoma SH-SY5Y cell line
(Elsevier, 2019-02-27)
Microcystin-LR (MC-LR) and Cylindrospermopsin (CYN) are produced by cyanobacteria. Although being considered as a hepatotoxin and a cytotoxin, respectively, different studies have revealed neurotoxic properties for both ...
Artículo
New Halonotius Species Provide Genomics-Based Insights Into Cobalamin Synthesis in Haloarchaea
(Frontiers Media, 2019)
Hypersaline aquatic and terrestrial ecosystems display a cosmopolitan distribution. These environments teem with microbes and harbor a plethora of prokaryotic lineages that evaded ecological characterization due to the ...
Artículo
Neuroprotective potential of verbascoside isolated from acanthus mollis l. Leaves through its enzymatic inhibition and free radical scavenging ability
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
The phenomenon of today’s ageing population has increased interest in the search for new active substances that delay the onset and development of neurodegenerative diseases. In this respect, the search for natural compounds, ...
Artículo
Data fusion approaches in spectroscopic characterization and classification of PDO wine vinegars
(Elsevier, 2019)
Spain is one of the major producers of high-quality wine vinegars having three protected designations of origin (a.k.a. PDOs): “Vinagre de Jerez”, “Vinagre de Condado de Huelva” and “Vinagre de Montilla-Moriles”. Their ...
Artículo
Printfills: 3D printed systems combining fused deposition modeling and injection volume filling. Application to colon-specific drug delivery
(Elsevier, 2019-01)
Three-dimensional printing has become a feasible manufacturing technique for pharmaceutical products providing cheap and accurate freeform systems with a great potential for personalized-dose drugs. Fused Deposition Modeling ...
Artículo
Impact of thermal treatments on the bioaccessibility of phytoene and phytofluene in relation to changes in the microstructure and size of orange juice particles
(Elsevier, 2018)
The interest in phytoene and phytofluene is expanding. In this study their bioaccessibility from thermally treated orange juices was analysed. Other carotenoids were also considered for comparison. Fresh, pasteurized, and ...
Artículo
Novel Findings about Double-Loaded Curcumin-in-HPβcyclodextrin-in Liposomes: Effects on the Lipid Bilayer and Drug Release
(MDPI, 2018-12)
In this study, the encapsulation of curcumin (Cur) in “drug-in-cyclodextrin-in-liposomes (DCL)” by following the double-loading technique (DL) was proposed, giving rise to DCL–DL. The aim was to analyze the effect of ...
Artículo
In Vitro Effects of Serotonin, Melatonin, and Other Related Indole Compounds on Amyloid-beta Kinetics and Neuroprotection
(Wiley, 2018)
Scope Amyloid-β peptide is the main component of senile plaques in Alzheimer's disease. The inhibition of amyloid-β peptide assembly, the destabilization of amyloid-β peptide aggregates, and the decrease of its cytotoxicity ...
Artículo
Early stages of drug crystallization from amorphous solid dispersion via fractal analysis based on chemical imaging
(Elsevier, 2018-12)
Early stages of crystallization from amorphous solid dispersion (ASD) are typically not detected by means of standard methods like powder X-ray diffraction (XRPD). The aim of this study is therefore to evaluate if fractal ...
Artículo
Phytoene and Phytofluene Isolated from a Tomato Extract are Readily Incorporated in Mixed Micelles and Absorbed by Caco-2 Cells, as Compared to Lycopene, and SR-BI is Involved in their Cellular Uptake
(Wiley-Blackwell, 2018)
Scope: Absorption mechanisms of phytoene (PT) and phytofluene (PTF) are poorly known. The main objectives of the study are to measure their micellization and intestinal cell uptake efficiencies and to compare them to those ...