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dc.contributor.editorOrtega Calvo, Manueles
dc.creatorPalacios Fernández,Nes
dc.creatorFrancisco Montero , C dees
dc.creatorGabaldón Rodríguez , Ies
dc.creatorCorchado Albalat, María Yolandaes
dc.creatorSantos Lozano, José Manueles
dc.creatorOrtega Calvo, Manueles
dc.date.accessioned2021-02-05T11:07:49Z
dc.date.available2021-02-05T11:07:49Z
dc.date.issued2020-12-10
dc.identifier.citationPalacios Fernández, , De Francisco Montero , C., Gabaldón Rodríguez , I., Corchado Albalat, M.Y., Santos Lozano, J.M. y Ortega Calvo, M. (2020). Correlaciones de biomarcadores del primer trimestre con el peso fetal y con el peso materno en embarazadas con diabetes gestacional.. Revista Argentina de Endocrinología y Metabolismo, 57 (4), 50-56.
dc.identifier.issn0326-4610es
dc.identifier.urihttps://hdl.handle.net/11441/104658
dc.description.abstractGiven the obstetric and metabolic importance of Gestational Diabetes, we wanted to study the correlations ofthe first trimester biomarkers with the weight ofthe fetus at 20 weeks and with that of the mother at 28 weeks of gestation for pregnant women with and without gestational diabetes in a research carried out in primary care. This is an observational study of cases and controls. The quantitative variables analyzed were: PAPPA (Pregnancy Associated Plasma Protein A) (mU / ml), Betahydroxychorionic (ngrs / ml), TSH (µUI / ml) and free T4 (ngrs / dl) at 12 weeks, fetal weight at 20 weeks and maternal weight in kilograms at 28 weeks. As a descriptive balancing variable, we have used the age of the pregnant woman in years. Six health centers of the Primary Healthcare District of Seville (Spain) have been sampled. We applied simple linear regression using the least squares method and the smoothing technique called LOESS (Locally Weighted Scatterplot Smoothing). A finding was highlighted above all the others, the inverse correlations and the least squares lines of the PAPP-A and TSH variables at 12 weeks of gestation, and the correlations between fetal weight at 20 weeks with Betahydroxychorionic and with PAPPA. The most important is the first because of the change and the magnitude of Pearson's R2 (+0.10) in pregnant women with gestational diabetes. We have found a noticeable change in the correlation of PAPPA with TSH in pregnant women with Gestational Diabetes. The upper confidence interval of the Pearson correlation coefficient reaches +0. 3 . A possible pathophysiological explanation for this correlation found in our work could be the action ofTSH on insulin-like growth factors in human osteoblastic cells.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.language.isospaes
dc.publisherSociedad Argentina de Endocrinología y Metabolismoes
dc.relation.ispartofRevista Argentina de Endocrinología y Metabolismo, 57 (4), 50-56.
dc.rightsAttribution-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/*
dc.subjectPregnancyes
dc.subjectGestational Diabeteses
dc.subjectRegression analysises
dc.subjectPlacental proteinses
dc.subjectPrimary Health Carees
dc.titleCorrelaciones de biomarcadores del primer trimestre con el peso fetal y con el peso materno en embarazadas con diabetes gestacional.es
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.contributor.groupCIBER - OBN. ISCIIIes
idus.validador.notaEste artículo ha surgido de un TFG del que fui director el curso pasado.es
dc.journaltitleRevista Argentina de Endocrinología y Metabolismoes
dc.publication.volumen57es
dc.publication.issue4es
dc.publication.initialPage50es
dc.publication.endPage56es

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Except where otherwise noted, this item's license is described as: Attribution-NoDerivatives 4.0 Internacional