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dc.creatorÁlvarez Escribano, Isidroes
dc.creatorBrenes Álvarez, Manueles
dc.creatorOlmedo Verd, Elvira dees
dc.creatorVioque Peña, Agustínes
dc.creatorMuro Pastor, Alicia Maríaes
dc.date.accessioned2020-10-01T16:27:51Z
dc.date.available2020-10-01T16:27:51Z
dc.date.issued2020
dc.identifier.citationÁlvarez Escribano, I., Brenes Álvarez, M., Olmedo Verd, E.d., Vioque Peña, A. y Muro Pastor, A.M. (2020). The nitrogen stress-repressed srna nsrr1 regulates expression of all1871, a gene required for diazotrophic growth in nostoc sp. Pcc 7120. Life, 10 (5), 54-.
dc.identifier.issn2075-1729es
dc.identifier.urihttps://hdl.handle.net/11441/101651
dc.description.abstractSmall regulatory RNAs (sRNAs) are post-transcriptional regulators of bacterial gene expression. In cyanobacteria, the responses to nitrogen availability, that are mostly controlled at the transcriptional level by NtcA, involve also at least two small RNAs, namely NsiR4 (nitrogen stress-induced RNA 4) and NsrR1 (nitrogen stress-repressed RNA 1). Prediction of possible mRNA targets regulated by NsrR1 in Nostoc sp. PCC 7120 allowed, in addition to previously described nblA, the identification of all1871, a nitrogen-regulated gene encoding a protein of unknown function that we describe here as required for growth at the expense of atmospheric nitrogen (N2). We show that transcription of all1871 is induced upon nitrogen step-down independently of NtcA. All1871 accumulation is repressed by NsrR1 and its expression is stronger in heterocysts, specialized cells devoted to N2 fixation. We demonstrate specific interaction between NsrR1 and the 5′ untranslated region (UTR) of the all1871 mRNA, that leads to decreased expression of all1871. Because transcription of NsrR1 is partially repressed by NtcA, post-transcriptional regulation by NsrR1 would constitute an indirect way of NtcA-mediated regulation of all1871.es
dc.description.sponsorshipMinisterio de Economía y Competitividad BFU2013-48282- C2-1-P, BFU2016-74943-C2-1-Pes
dc.formatapplication/pdfes
dc.format.extent16 p.es
dc.language.isoenges
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es
dc.relation.ispartofLife, 10 (5), 54-.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCyanobacteriaes
dc.subjectHeterocystes
dc.subjectPost-transcriptional regulationes
dc.subjectRegulatory RNAes
dc.titleThe nitrogen stress-repressed srna nsrr1 regulates expression of all1871, a gene required for diazotrophic growth in nostoc sp. Pcc 7120es
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Moleculares
dc.relation.projectIDBFU2013-48282- C2-1-Pes
dc.relation.projectIDBFU2016-74943-C2-1-Pes
dc.relation.publisherversionhttps://doi.org/10.3390/life10050054es
dc.identifier.doi10.3390/life10050054es
dc.journaltitleLifees
dc.publication.volumen10es
dc.publication.issue5es
dc.publication.initialPage54es

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