dc.creator | Baus Domínguez, María | es |
dc.creator | Gómez Díaz, Raquel | es |
dc.creator | Corcuera Flores, José Ramón | es |
dc.creator | Torres-Lagares, Daniel | es |
dc.creator | Ruiz-Villandiego, José-Cruz | es |
dc.creator | Machuca-Portillo, Guillermo | es |
dc.creator | Gutiérrez Pérez, José Luis | es |
dc.creator | Serrera Figallo, María de los Ángeles | es |
dc.date.accessioned | 2020-09-14T18:20:28Z | |
dc.date.available | 2020-09-14T18:20:28Z | |
dc.date.issued | 2019-09-14 | |
dc.identifier.citation | Baus Domínguez, M., Gómez Díaz, R., Corcuera Flores, J.R., Torres-Lagares, D., Ruiz-Villandiego, J., Machuca-Portillo, G.,...,Serrera Figallo, M.d.l.Á. (2019). Metallothioneins in Failure of Dental Implants and Periodontitis Down Syndrome Patients. Genes, 10 (9), 711-. | |
dc.identifier.issn | 2073-4425 | es |
dc.identifier.uri | https://hdl.handle.net/11441/101093 | |
dc.description.abstract | Background: Sometimes dental implants seem to be the only therapeutic alternative for
the oral rehabilitation of patients with Down syndrome, given that they usually lose all their teeth
early due to suffering aggressive periodontitis and they do not usually have the skills required to
wear removable prostheses. However, the evolution of dental implants in these patients shows
very adverse results. It is possible that basal genetic alterations, or at least some characteristics of
these, may underlie these clinical results. The metabolic pathway of metallothioneins, molecules
with an important influence on bone metabolism, could be one of the said alterations. Aims: To
determine whether the expression of metallothioneins (MTs) and their metabolic pathway may be
identified and related to the periodontitis and lack of osseointegration of dental implants in Down
syndrome patients. Materials and Methods: Retrospective study of cases and controls by comparing
patients with Down syndrome, periodontal disease, and implant failure (four patients, test group)
with patients with Down syndrome, without periodontal disease, and without implant failure after
two years of following (seven patients, control group), by extracting peripheral blood at the time of
the dental examination to extract RNA and its subsequent processing in relation to gene expression
of the metabolic pathway of metallothioneins. Results: The results identified low expression in
the group of patients with periodontal disease and implant failure of genes MT1E, MT1H, MT1X,
MT1A, MT1B, MT1C, MT1L, MT2A, MT1M, and MT1G. Conclusions: The low MT1 and MT2 gene
expression seems to be related to the onset of periodontal disease and implant rejection in Down
syndrome patients, although more data are required to confirm whether this relationship is due to one
of the two conditions, to both independently, or to the two jointly—this last option being indicated by
our current study | es |
dc.description.sponsorship | Junta de Andalucía Consejería de Salud PI-0081-2016 | es |
dc.format | application/pdf | es |
dc.format.extent | 12 | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Genes, 10 (9), 711-. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Bone biology | es |
dc.subject | Clinical outcomes | es |
dc.subject | Gene expression | es |
dc.subject | Systemic health | es |
dc.subject | Systemic disease | es |
dc.subject | Osseointegration | es |
dc.subject | Periodontal disease | es |
dc.subject | Down syndrome | es |
dc.title | Metallothioneins in Failure of Dental Implants and Periodontitis Down Syndrome Patients | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estomatología | es |
dc.relation.projectID | PI-0081-2016 | es |
dc.identifier.doi | 10.3390/genes10090711 | es |
dc.journaltitle | Genes | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 9 | es |
dc.publication.initialPage | 711 | es |