Artículo
The Application of Statins in the Regeneration of Bone Defects. Systematic Review and Meta-Analysis
Autor/es | Roca-Millan, Elisabeth
González-Navarro, Beatríz Izquierdo-Gómez, Keila Marí-Roig, Antonio Jané-Salas, Enric López López, José Velasco-Ortega, Eugenio |
Departamento | Universidad de Sevilla. Departamento de Estomatología |
Fecha de publicación | 2019-09-16 |
Fecha de depósito | 2020-09-14 |
Publicado en |
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Resumen | This systematic review aims to analyze the effect of the local application of statins
in the regeneration of non-periodontal bone defects. A systematic study was conducted with
the Pubmed/Medline, Embase, Cochrane Library ... This systematic review aims to analyze the effect of the local application of statins in the regeneration of non-periodontal bone defects. A systematic study was conducted with the Pubmed/Medline, Embase, Cochrane Library and Scielo databases for in vivo animal studies published up to and including February 2019. Fifteen articles were included in the analysis. The local application of the drug increased the percentage of new bone formation, bone density, bone healing, bone morphogenetic protein 2, vascular endothelial growth factor, progenitor endothelial cells and osteocalcin. Meta-analyses showed a statistically significant increase in the percentage of new bone formation when animals were treated with local statins, in contrast to the no introduction of filling material or the introduction of polylactic acid, both in an early (4–6 weeks) and in a late period (12 weeks) (mean difference 39.5%, 95% confidence interval: 22.2–56.9, p <0.001; and mean difference 43.3%, 95% confidence interval: 33.6–52.9, p < 0.001, respectively). Basing on the animal model, the local application of statins promotes the healing of critical bone size defects due to its apparent osteogenic and angiogenic effects. However, given the few studies and their heterogenicity, the results should be taken cautiously, and further pilot studies are necessary, with radiological and histological evaluations to translate these results to humans and establish statins’ effect |
Cita | Roca-Millan, E., González-Navarro, B., Izquierdo-Gómez, K., Marí-Roig, A., Jané-Salas, E., López López, J. y Velasco-Ortega, E. (2019). The Application of Statins in the Regeneration of Bone Defects. Systematic Review and Meta-Analysis. Materials, 12 (18), 2992. https://doi.org/10.3390/ma12182992. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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materials-12-02992.pdf | 1.916Mb | [PDF] | Ver/ | Application of Statins |