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dc.creatorSerrera Figallo, María de los Ángeleses
dc.creatorRuiz de León Hernández,Gonzaloes
dc.creatorTorres-Lagares, Danieles
dc.creatorCastro-Araya, Alejandraes
dc.creatorTorres-Ferrerosa, Omares
dc.creatorHernández-Pacheco Camarero, Estheres
dc.creatorGutiérrez Pérez, José Luises
dc.date.accessioned2020-08-24T10:34:25Z
dc.date.available2020-08-24T10:34:25Z
dc.date.issued2020
dc.identifier.citationSerrera Figallo, M.d.l.Á., Ruiz de León Hernández, o., Torres-Lagares, D., Castro-Araya, A., Torres-Ferrerosa, O., Hernández-Pacheco Camarero, E. y Gutiérrez Pérez, J.L. (2020). Use of Botulinum Toxin in Orofacial Clinical Practice. Toxins, 12 (112), 1-16.
dc.identifier.issn2072-6651es
dc.identifier.urihttps://hdl.handle.net/11441/100369
dc.description.abstractBotulinum neurotoxin (BoNT) is a potent biological toxin and powerful therapeutic tool for a growing number of clinical orofacial applications. BoNT relaxes striated muscle by inhibiting acetylcholine’s release from presynaptic nerve terminals, blocking the neuromuscular junction. It also has an antinociceptive effect on sensory nerve endings, where BoNT and acetylcholine are transported axonally to the central nervous system. In dentistry, controlled clinical trials have demonstrated BoNT’s efficiency in pathologies such as bruxism, facial paralysis, temporomandibular joint (TMJ) disorders, neuropathic pain, sialorrhea, dystonia and more. Aim: This study’s aim was to conduct a systematic literature review to assess the most recent high-level clinical evidence for BoNT’s efficacy and for various protocols (the toxin used, dilution, dosage and infiltration sites) used in several orofacial pathologies. Materials and methods: We systematically searched the MedLine database for research papers published from 2014 to 2019 with randomly allocated studies on humans. The search included the following pathologies: bruxism, dislocation of the TMJ, orofacial dystonia, myofascial pain, salivary gland disease, orofacial spasm, facial paralysis, sialorrhea, Frey syndrome and trigeminal neuralgia. Results: We found 228 articles, of which only 20 met the inclusion criteria: bruxism (four articles), orofacial dystonia (two articles), myofascial pain (one article), salivary gland disease (one article), orofacial spasm (two articles), facial paralysis (three articles), sialorrhea (four articles) or trigeminal neuralgia (three articles). Discussion: The clinical trials assessed showed variations in the dosage, application sites and musculature treated. Thus, applying BoNT can reduce symptoms related to motor muscular activity in the studied pathologies efficiently enough to satisfy patients. We did not identify the onset of any important side effects in the literature reviewed. We conclude that treatment with BoNT seems a safe and effective treatment for the reviewed pathologieses
dc.formatapplication/pdfes
dc.format.extent16es
dc.language.isoenges
dc.relation.ispartofToxins, 12 (112), 1-16.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBotulinum toxines
dc.subjectBruxismes
dc.subjectSalivary fistulaes
dc.subjectFacial spasmes
dc.subjectSialorrheaes
dc.subjectOrofacial dystoniaes
dc.subjectMyofascial paines
dc.subjectFacial paralysises
dc.subjectFrey syndromees
dc.subjectLockjawes
dc.subjectTrigeminal neuralgiaes
dc.titleUse of Botulinum Toxin in Orofacial Clinical Practicees
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Estomatologíaes
dc.relation.publisherversiondoi:10.3390/toxins12020112es
dc.journaltitleToxinses
dc.publication.volumen12es
dc.publication.issue112es
dc.publication.initialPage1es
dc.publication.endPage16es

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