dc.creator | Serrera Figallo, María de los Ángeles | es |
dc.creator | Ruiz de León Hernández,Gonzalo | es |
dc.creator | Torres-Lagares, Daniel | es |
dc.creator | Castro-Araya, Alejandra | es |
dc.creator | Torres-Ferrerosa, Omar | es |
dc.creator | Hernández-Pacheco Camarero, Esther | es |
dc.creator | Gutiérrez Pérez, José Luis | es |
dc.date.accessioned | 2020-08-24T10:34:25Z | |
dc.date.available | 2020-08-24T10:34:25Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Serrera Figallo, M.d.l.Á., Ruiz de León Hernández, o., Torres-Lagares, D., Castro-Araya, A., Torres-Ferrerosa, O., Hernández-Pacheco Camarero, E. y Gutiérrez Pérez, J.L. (2020). Use of Botulinum Toxin in Orofacial Clinical Practice. Toxins, 12 (112), 1-16. | |
dc.identifier.issn | 2072-6651 | es |
dc.identifier.uri | https://hdl.handle.net/11441/100369 | |
dc.description.abstract | Botulinum neurotoxin (BoNT) is a potent biological toxin and powerful therapeutic tool for a growing number of clinical orofacial applications. BoNT relaxes striated muscle by inhibiting acetylcholine’s release from presynaptic nerve terminals, blocking the neuromuscular junction. It also has an antinociceptive effect on sensory nerve endings, where BoNT and acetylcholine are transported axonally to the central nervous system. In dentistry, controlled clinical trials have demonstrated BoNT’s efficiency in pathologies such as bruxism, facial paralysis, temporomandibular joint (TMJ) disorders, neuropathic pain, sialorrhea, dystonia and more. Aim: This study’s aim was to conduct a systematic literature review to assess the most recent high-level clinical evidence
for BoNT’s efficacy and for various protocols (the toxin used, dilution, dosage and infiltration
sites) used in several orofacial pathologies. Materials and methods: We systematically searched
the MedLine database for research papers published from 2014 to 2019 with randomly allocated
studies on humans. The search included the following pathologies: bruxism, dislocation of the TMJ,
orofacial dystonia, myofascial pain, salivary gland disease, orofacial spasm, facial paralysis, sialorrhea,
Frey syndrome and trigeminal neuralgia. Results: We found 228 articles, of which only 20 met the
inclusion criteria: bruxism (four articles), orofacial dystonia (two articles), myofascial pain (one article),
salivary gland disease (one article), orofacial spasm (two articles), facial paralysis (three articles),
sialorrhea (four articles) or trigeminal neuralgia (three articles). Discussion: The clinical trials assessed
showed variations in the dosage, application sites and musculature treated. Thus, applying BoNT can
reduce symptoms related to motor muscular activity in the studied pathologies efficiently enough
to satisfy patients. We did not identify the onset of any important side effects in the literature
reviewed. We conclude that treatment with BoNT seems a safe and effective treatment for the
reviewed pathologies | es |
dc.format | application/pdf | es |
dc.format.extent | 16 | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Toxins, 12 (112), 1-16. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Botulinum toxin | es |
dc.subject | Bruxism | es |
dc.subject | Salivary fistula | es |
dc.subject | Facial spasm | es |
dc.subject | Sialorrhea | es |
dc.subject | Orofacial dystonia | es |
dc.subject | Myofascial pain | es |
dc.subject | Facial paralysis | es |
dc.subject | Frey syndrome | es |
dc.subject | Lockjaw | es |
dc.subject | Trigeminal neuralgia | es |
dc.title | Use of Botulinum Toxin in Orofacial Clinical Practice | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estomatología | es |
dc.relation.publisherversion | doi:10.3390/toxins12020112 | es |
dc.journaltitle | Toxins | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 112 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 16 | es |