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dc.creatorVarela-López, Alfonsoes
dc.creatorBullon, Pedroes
dc.creatorRamírez-Tortosa, César L.es
dc.creatorNavarro-Hortal, María D.es
dc.creatorRobles-Almazán, Maríaes
dc.creatorBullón de la Fuente, Beatrizes
dc.creatorQuiles, José L.es
dc.date.accessioned2020-08-20T17:22:46Z
dc.date.available2020-08-20T17:22:46Z
dc.date.issued2020
dc.identifier.citationVarela-López, A., Bullon, P., Ramírez-Tortosa, C.L., Navarro-Hortal, M.D., Robles-Almazán, M., Bullón Fernández, B. y Quiles, J.L. (2020). A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease. Nutrients, 12 (5)
dc.identifier.issn2072-6643es
dc.identifier.urihttps://hdl.handle.net/11441/100317
dc.description.abstractIncreasing evidence connects periodontitis with a variety of systemic diseases, including metabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). The proposal of this study was to evaluate the role of diets rich in saturated fat and cholesterol in some aspects of periodontal diseases in a lipopolysaccharide (LPS)-induced model of periodontal disease in rabbits and to assess the influence of a periodontal intervention on hyperlipidemia, atherosclerosis, and NAFLD progression to non-alcoholic steatohepatitis. Male rabbits were maintained on a commercial standard diet or a diet rich in saturated fat (3% lard w/w) and cholesterol (1.3% w/w) (HFD) for 40 days. Half of the rabbits on each diet were treated 2 days per week with intragingival injections of LPS from Porphyromonas gingivalis. Morphometric analyses revealed that LPS induced higher alveolar bone loss (ABL) around the first premolar in animals receiving standard diets, which was exacerbated by the HFD diet. A higher score of acinar inflammation in the liver and higher blood levels of triglycerides and phospholipids were found in HFD-fed rabbits receiving LPS. These results suggest that certain dietary habits can exacerbate some aspects of periodontitis and that bad periodontal health can contribute to dyslipidemia and promote NAFLD progression, but only under certain conditions.es
dc.formatapplication/pdfes
dc.format.extent16es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofNutrients, 12 (5)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAtherogenices
dc.subjectAtherosclerosises
dc.subjectNASHes
dc.subjectNon-alcoholic fatty liver diseasees
dc.subjectPeriodontal diseaseses
dc.subjectPeriodontitises
dc.subjectRabbitses
dc.titleA Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Diseasees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Estomatologíaes
dc.relation.publisherversionhttps://doi.org/10.3390/nu12051405es
dc.identifier.doi10.3390/nu12051405es
dc.journaltitleNutrientses
dc.publication.volumen12es
dc.publication.issue5es

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