Artículo
Single -and Multi-Walled Carbon Nanotubes as Nanocarriers for the Delivery of 7-Hydroxyflavone
Autor/es | Espíndola, Cecilia
Correa, Alejandro Javier López López, Manuel López-Cornejo, María del Pilar Bernal Pérez, Eva Lebrón Romero, José Antonio Ostos Marcos, Francisco José Rafii-El-Idrissi Benhnia, Mohammed Moyá Morán, María Luisa |
Departamento | Universidad de Sevilla. Departamento de Química Física Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2022 |
Fecha de depósito | 2023-09-08 |
Publicado en |
|
Resumen | The research on flavonoids has exponentially grown since their first therapeutic evidence, in 1937. They are effective in vitro in a wide range of human diseases, particularly those mediated by free radicals, such as cancer, ... The research on flavonoids has exponentially grown since their first therapeutic evidence, in 1937. They are effective in vitro in a wide range of human diseases, particularly those mediated by free radicals, such as cancer, atherosclerosis, AIDS, or neuronal diseases. However, their applications have been reduced due to their low solubility, poor absorption, and rapid metabolism. Flavonoid encapsulation in nanocarriers significantly improves their oral absorption, protects the drug against degradation, decreases the first-pass hepatic effect, and makes absorption through the lymphatic system easier. In this work, carbon nanotubes were used as nanocarriers of 7-hydroxyflavone, 7-HF. The encapsulation of 7-HF into pristine single- and multi-walled carbon nanotubes, and into -COOH functionalized single-walled carbon nanotubes has been investigated. The equilibrium association constants were estimated. The structural backbone of 7-HF, two benzene rings linked through three carbon atoms that form a pyran heterocyclic ring containing a keto group, seems to play a key role in the 7-HF/CNT interactions, although other types of interactions are also at work. The in vitro release of 7-HF was studied at three pHs, 2.0, 7.4, and 9.2, mimicking the different biological barriers of the human organism. |
Agencias financiadoras | Junta de Andalucía Universidad de Sevilla European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Identificador del proyecto | FQM-206
FQM-274 2018/500 |
Cita | Espíndola, C., Correa, A.J., López López, M., López-Cornejo, M.d.P., Bernal Pérez, E., Lebrón Romero, J.A.,...,Moyá Morán, M.L. (2022). Single -and Multi-Walled Carbon Nanotubes as Nanocarriers for the Delivery of 7-Hydroxyflavone. Pharmaceutics, 14 (12), 2806. https://doi.org/10.3390/pharmaceutics14122806. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Single -and multi-walled carbon.pdf | 2.611Mb | [PDF] | Ver/ | |