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Listar por autor "Romero Pérez, Laura"
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High specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG positive Ewing sarcoma
Orth, Martin F.; Hölting, Tilman L.B.; Dallmayer, Marlene; Wehweck, Fabienne S.; Paul, Tanja; Musa, Julian; Romero Pérez, Laura; Grünewald, Thomas G.P. (MDPI, 2020)Ewing sarcoma (EwS) is an aggressive cancer displaying an undifferentiated small-round-cell histomorphology that can be ...
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Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma
Rodríguez-Núñez, Pablo; Romero Pérez, Laura; Amaral, Ana T.; Puerto-Camacho, Pilar; Jordán, Carmen; Marcilla, David; Álava Casado, Enrique de; Díaz-Martín, Juan (Wiley, 2020)YAP1 and TAZ (WWTR1) oncoproteins are thefinal transducers of the Hippo tumor suppressor pathway. Deregula-tion of the ...
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Improving the management of Inherited Retinal Dystrophies by targeted sequencing of a population-specific gene panel
Bravo Gil, Nereida Inés; Méndez Vidal, Cristina; Romero Pérez, Laura; González del Pozo, María; Rodríguez de la Rúa Franch, Enrique; Dopazo, Joaquín; Antiñolo Gil, Guillermo (Springer Nature, 2016)Next-generation sequencing (NGS) has overcome important limitations to the molecular diagnosis of Inherited Retinal ...
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Integrative clinical transcriptome analysis reveals TMPRSS2-ERG dependency of prognostic biomarkers in prostate adenocarcinoma
Gerke, Julia S.; Orth, Martin F.; Tolkach, Yuri; Romero Pérez, Laura; Wehweck, Fabienne S.; Stein, Stefanie; Grünewald, Thomas G. P. (Wiley, 2020)In prostate adenocarcinoma (PCa), distinction between indolent and aggressive disease is challenging. Around 50% of PCa ...
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Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma
Cidre-Aranaz, Florencia; Li, Jing; Hölting, Tilman L.B.; Tilman L.B.; Orth, Martin F.; Imle, Roland; Romero Pérez, Laura; Grünewald, Thomas G.P. (Biomed Central LTD, 2022) -
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MicroRNA-200 Family Modulation in Distinct Breast Cancer Phenotypes
Isacke, Clare M.; Díaz Martín, Juan; Ramiro Fuentes, Susana María; López García, María de los Ángeles; Castilla Moro, Mª Ángeles; Palacios Calvo, José; Vieites Pérez-Quintela, Begoña; Romero Pérez, Laura; Biscuola, Michele; Sarrio, David (2012) -
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Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
Marchetto, Aruna; Ohmura, Shunya; Orth, Martin F.; Knott, Maximilian M.L.; Colombo, Maria V.; Romero Pérez, Laura (Nature Publishing Group, 2020)Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells or osteo-chondrogenic ...
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Sarcoma classification by DNA methylation profiling
Koelsche, Christian; Schrimpf, Daniel; Stichel, Damian; Sill, Martin; Sahm, Felix; Reuss, David E.; Romero Pérez, Laura; Álava Casado, Enrique de; Idoate Gastearena, Miguel Ángel; Hohenberger, Peter (Nature Publishing Ggroup, 2021)Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a ...
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Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
Li, Jing; Ohmura, Shunya; Marchetto, Aruna; Orth, Martin F.; Imle, Roland; Dallmayer, Marlene; Romero Pérez, Laura; Grünewald, Thomas G. P. (Nature Research, 2021-09-16)Chromosomal instability (CIN) is a hallmark of cancer1. Yet, many childhood cancers, such as Ewing sarcoma (EwS), feature ...
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Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma
Ohmura, Shunya; Marchetto, Aruna; Orth, Martin F.; Li, Jing; Jabar, Susanne; Ranft, Andreas; Romero Pérez, Laura; Grünewald, Thomas G. P. (BMC, 2021-07-27)Ewing sarcoma (EwS) is an aggressive bone- or soft tissue-associated malignancy, characterised by the fusion oncoprotein ...