- idUS
- Browsing by Author
Browsing by Author "Orzáez, Mar"
Now showing items 1-3 of 3
-
Article
Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition
Elena-Real, Carlos A.; Díaz Quintana, Antonio Jesús; González Arzola, Katiuska; Velázquez Campoy, Adrián; Orzáez, Mar; López Rivas, Abelardo; Gil Caballero, Sergio; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Nature Publishing Group, 2018)Apoptosis is a highly regulated form of programmed cell death, essential to the development and homeostasis of multicellular ...
-
Article
Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation
García Heredia, José Manuel; Díaz Moreno, Irene; Nieto Mesa, Pedro Manuel; Orzáez, Mar; Kocanis, Stella; Teixeira, Miguel; Pérez Payá, Enrique; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Elsevier, 2010)Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure ...
-
Article
Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome
García Heredia, José Manuel; Díaz Moreno, Irene; Díaz Quintana, Antonio Jesús; Orzáez, Mar; Navarro Carruesco, José Antonio; Hervás Morón, Manuel; Rosa Acosta, Miguel Ángel de la (Elsevier, 2012)Under nitroxidative stress, a minor fraction of cytochrome c can be modified by tyrosine nitration. Here we analyze the ...