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Listar por autor "Orth, Martin F."
Mostrando ítems 1-6 de 6
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High specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG positive Ewing sarcoma
Orth, Martin F.; Hölting, Tilman L.B.; Dallmayer, Marlene; Wehweck, Fabienne S.; Paul, Tanja; Musa, Julian; Romero Pérez, Laura; Grünewald, Thomas G.P. (MDPI, 2020)Ewing sarcoma (EwS) is an aggressive cancer displaying an undifferentiated small-round-cell histomorphology that can be ...
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Integrative clinical transcriptome analysis reveals TMPRSS2-ERG dependency of prognostic biomarkers in prostate adenocarcinoma
Gerke, Julia S.; Orth, Martin F.; Tolkach, Yuri; Romero Pérez, Laura; Wehweck, Fabienne S.; Stein, Stefanie; Grünewald, Thomas G. P. (Wiley, 2020)In prostate adenocarcinoma (PCa), distinction between indolent and aggressive disease is challenging. Around 50% of PCa ...
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Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma
Cidre-Aranaz, Florencia; Li, Jing; Hölting, Tilman L.B.; Tilman L.B.; Orth, Martin F.; Imle, Roland; Romero Pérez, Laura; Grünewald, Thomas G.P. (Biomed Central LTD, 2022) -
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Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
Marchetto, Aruna; Ohmura, Shunya; Orth, Martin F.; Knott, Maximilian M.L.; Colombo, Maria V.; Romero Pérez, Laura (Nature Publishing Group, 2020)Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells or osteo-chondrogenic ...
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Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
Li, Jing; Ohmura, Shunya; Marchetto, Aruna; Orth, Martin F.; Imle, Roland; Dallmayer, Marlene; Romero Pérez, Laura; Grünewald, Thomas G. P. (Nature Research, 2021-09-16)Chromosomal instability (CIN) is a hallmark of cancer1. Yet, many childhood cancers, such as Ewing sarcoma (EwS), feature ...
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Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma
Ohmura, Shunya; Marchetto, Aruna; Orth, Martin F.; Li, Jing; Jabar, Susanne; Ranft, Andreas; Romero Pérez, Laura; Grünewald, Thomas G. P. (BMC, 2021-07-27)Ewing sarcoma (EwS) is an aggressive bone- or soft tissue-associated malignancy, characterised by the fusion oncoprotein ...