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Browsing by Author "Martínez García, Pedro Manuel"
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Article
Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency
Álvarez Quilón, Alejandro; Terrón Bautista, José; Delgado Sainz, Irene; Serrano Benítez, Almudena; Romero Granados, Rocío; Martínez García, Pedro Manuel; Jimeno González, Silvia; Bernal Lozano, Cristina; Quintero, Cristina; García Quintanilla, Lourdes; Cortés Ledesma, Felipe (Springer Nature, 2020)The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established ...
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Article
Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
Herrero Ruiz, Andrés M.; Martínez García, Pedro Manuel; Terrón Bautista, José; Millán Zambrano, Gonzalo; Lieberman, Jenna Ariel; Jimeno González, Silvia; Cortés Ledesma, Felipe (Elsevier, 2021)Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol ...