Por motivos de mantenimiento se ha deshabilitado el inicio de sesión temporalmente. Rogamos disculpen las molestias.
Listar por autor "Gómez González, Belén"
Mostrando ítems 1-20 de 39
-
Artículo
A CDK-regulated chromatin segregase promoting chromosome replication
(Springer Nature, 2021)The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can ...
-
Artículo
A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
(Taylor & Francis, 2021)In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the ...
-
Artículo
A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination
(Public Library of Science, 2017)Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to ...
-
Artículo
A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability
(Genetics Society of America, 2022)The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be ...
-
Artículo
Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex
(National Academy of Sciences, 2007)Activation-induced cytidine deaminase (AID) is a B cell enzyme essential for Ig somatic hypermutation and class switch ...
-
Artículo
AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants
(Public Library of Science, 2011)Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by ...
-
Capítulo de Libro
Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast
(Elsevier, 2021)The repair of DNA double-strand breaks is crucial for cell viability and the maintenance of genome integrity. When present, ...
-
Artículo
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair
(Wiley-Blackwell, 2021)The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. ...
-
Artículo
Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
(Wiley-Blackwell, 2023)Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome ...
-
Artículo
Chromosomal translocations caused by either Pol32-dependent or Pol32-independent triparental break-induced replication
(American Society for Microbiology, 2009)Double-strand breaks (DSBs) are harmful DNA lesions that can generate chromosomal rearrangements or chromosome losses if ...
-
Artículo
Dna-rna hybrids at dsbs interfere with repair by homologous recombination
(eLife Sciences Publications, 2021)DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ...
-
Artículo
DNA-RNA hybrids: The risks of DNA breakage during transcription
(Springer Nature, 2017)Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ...
-
Artículo
Editorial: The Role of RNA in Genome Stability: To Wreck or Repair?
(Frontiers Media S.A., 2022) -
Artículo
Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
(Public Library of Science, 2011)THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ...
-
Artículo
Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
(Shared Science Publishers OG, 2019)Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These ...
-
Artículo
Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner
(eLife Sciences Publications, 2020)DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ...
-
Artículo
Heterogeneity of DNA damage incidence and repair in different chromatin contexts
(Elsevier, 2021)It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent ...
-
Artículo
Histone deacetylases facilitate the accurate repair of broken forks
(Taylor & Francis, 2020)We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 ...
-
Artículo
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
(Shared Science Publishers OG, 2020)The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...
-
Artículo
Histone Mutants Separate R Loop Formation from Genome Instability Induction
(Elsevier, 2017)R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ...