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Listar por autor "Aguilera López, Andrés"
Mostrando ítems 41-60 de 153
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Artículo
Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
Zatreanu, Diana; Han, Zhong; Mitter, Richard; Tumini, Emanuela; Williams, Hannah C.; Gregersen, Lea Haarup; Dirac-Svejstrup, A. Barbara; Roma, Stefania; Stewart, Aengus; Aguilera López, Andrés; Svejstrup, Jesper (Elsevier, 2019)Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been ...
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Artículo
Epigenetic features of human telomeres
Cubiles de la Vega, María Dolores; Barroso Ceballos, Sonia Inés; Vaquero Sedas, María Isabel; Enguix González, Alicia; Aguilera López, Andrés; Vega Palas, Miguel Ángel (Oxford University Press, 2018)Although subtelomeric regions in humans are heterochromatic, the epigenetic nature of human telomeres remains controversial. ...
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Artículo
Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening
Gavaldá Martín, Sandra; Santos Pereira, José María; García Rubio, María Luisa; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2016)Yra1 is an essential nuclear factor of the evolutionarily conserved family of hnRNP-like export factors that when overexpressed ...
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Artículo
Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability
Lafuente Barquero, Juan Francisco; Svejstrup, Jesper Q.; Luna Varo, Rosa María; Aguilera López, Andrés (Springer Nature, 2024-05-26)RECQL5 is a member of the conserved RecQ family of DNA helicases involved in the maintenance of genome stability that is ...
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Artículo
FANCD2 facilitates replication through common fragile sites
Madireddy, Advaitha; Aguilera López, Andrés; Herrera Moyano, Emilia; García Rubio, María Luisa; Owen, Nichole; Olson, Susan (Elsevier, 2016)Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the ...
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Artículo
Gene gating at nuclear pores prevents the formation of R loops
Gaillard, Hélène; García Benítez, Francisco; Aguilera López, Andrés (Taylor and Francis Ltd., 2018)Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation ...
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Tesis Doctoral
Genética y fisiología de la tolerancia al etanol en "Saccharomyces cerevisiae"
Aguilera López, Andrés (1983)En este trabajo se ha determinado el papel que juegan la herencia citoplasmática y la nuclear en la tolerancia al etanol ...
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Artículo
Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
Domínguez Sánchez, María Salud; Barroso Ceballos, Sonia Inés; Gómez González, Belén; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2011)THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ...
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Artículo
Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair
Gaillard, Hélène; Tous Rivera, Cristina; Botet, Javier; González Aguilera, Cristina; Quintero, María José; Viladevall, Laia; García Rubio, María Luisa; Rodríguez Gil, Alfonso; Marín, Antonio; Ariño, Joaquín; Revuelta, José Luis; Chávez de Diego, Sebastián; Aguilera López, Andrés (Public Library of Science, 2009)RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for ...
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Tesis Doctoral
Global Dynamics of Topoisomerase II Activity
Terrón Bautista, José (2022-04-22)DNA topoisomerases are key enzymes in charge of solving topological problems that arise from essential processes of DNA ...
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Artículo
Guidelines and recommendations on yeast cell death nomenclature
Carmona Gutiérrez, D.; Bauer, M. A.; Zimmermann, A.; Aguilera López, Andrés; Austriaco, N.; Ayscough, K.; Balzan, R.; Bar-Nun, S.; Madeo, F. (Shared Science Publishers, 2018)Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of ...
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Artículo
Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
Klein, Hannah L.; Bačinskaja, Giedré; Che, Jun; Cheblal, Anais; Elango, Rajula; Epshtein, Anastasiya; Fitzgerald, Devon M.; Gómez González, Belén; Khan, Sharik R.; Kumar, Sandeep Mothish; Leland, Bryan A.; Marie, Léa; Aguilera López, Andrés (Shared Science Publishers OG, 2019)Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These ...
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Artículo
Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner
Lafuente Barquero, Juan; García Rubio, María Luisa; San Martín Alonso, Marta; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2020)DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ...
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Artículo
Harmful R-loops are prevented via different cell cycle-specific mechanisms
San Martín Alonso, Marta; Soler Oliva, María Eugenia; García Rubio, María Luisa; García Muse, Tatiana; Aguilera López, Andrés (Springer Nature, 2021)Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by ...
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Artículo
Heterogeneity of DNA damage incidence and repair in different chromatin contexts
Ortega Moreno, Pedro; Gómez González, Belén; Aguilera López, Andrés (Elsevier, 2021)It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent ...
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Artículo
High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast
Andersen, Sabrina L.; Zhang, Aimee; Dominska, Margaret; Moriel Carretero, María; Herrera Moyano, Emilia; Aguilera López, Andrés (Public Library of Science, 2016)The Saccharomyces cerevisae RAD3 gene is the homolog of human XPD, an essential gene encoding a DNA helicase of the TFIIH ...
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Artículo
Histone deacetylases facilitate the accurate repair of broken forks
Gómez González, Belén; Ortega Moreno, Pedro; Aguilera López, Andrés (Taylor & Francis, 2020)We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 ...
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Artículo
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
Ortega Moreno, Pedro; García Pichardo, Desiré; San Martín Alonso, Marta; García Rondón, Ana; Gómez González, Belén; Aguilera López, Andrés (Shared Science Publishers OG, 2020)The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...
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Artículo
Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid
Muñoz Galván, Sandra; Jimeno González, Sonia; Rothstein, Rodney; Aguilera López, Andrés (Public Library of Science, 2013)DNA double-strand breaks (DSBs) are harmful lesions that arise mainly during replication. The choice of the sister chromatid ...
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Artículo
Histone Mutants Separate R Loop Formation from Genome Instability Induction
García Pichardo, Desiré; Cañas, Juan C.; García Rubio, María Luisa; Gómez González, Belén; García Rondón, Ana; Aguilera López, Andrés (Elsevier, 2017)R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ...