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Listar por autor "Gómez González, Belén"
Mostrando ítems 21-35 de 35
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Artículo
R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX
Aguilera López, Andrés; Gómez González, Belén (2009) -
Artículo
Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
Aguilera López, Andrés; Gómez González, Belén; Ortega Moreno, Pedro (Nature Research, 2019)Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, ...
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Artículo
Rpd3l contributes to the DNA damage sensitivity of saccharomyces cerevisiae checkpoint mutants
Gómez González, Belén; Patel, Harshil M.; Early, Anne; Diffley, John F.X. (Genetics Society of America, 2019)DNA replication forks that are stalled by DNA damage activate an S-phase checkpoint that prevents irreversible fork arrest ...
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Artículo
Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
Gómez González, Belén; Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Aguilera López, Andrés (Taylor & Francis, 2020)A large body of research supports that transcription plays a major role among the many sources of replicative stress ...
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Artículo
The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins
Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Muñoz Sánchez, Sergio; García Rubio, María Luisa; Gómez González, Belén; Aguilera López, Andrés (EMBO Press, 2019-07-24)Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ...
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Tesis Doctoral
The influence of chromatin in DNA-RNA hybrid metabolism
Martínez Cañas, Juan Carlos (2020-07-07)El genoma, el conjunto de genes de un organismo o especie, debe copiarse de forma fidedigna de célula a célula. Sin ...
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Artículo
The need to regulate replication fork speed
Gómez González, Belén; Aguilera López, Andrés (American Association for the Advancement of Science, 2017) -
Artículo
The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
Bermejo, Rodrigo; Gómez González, Belén; Aguilera López, Andrés; Foiani, Marco; Capra, Thelma; Cocito, Andrea (Elsevier, 2011)Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. ...
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Artículo
The Role of Replication-Associated Repair Factors on R-Loops
Bhatia, Vaibhav; Herrera Moyano, Emilia; Aguilera López, Andrés; Gómez González, Belén (MDPI, 2017)The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) ...
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Artículo
The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants
Gómez González, Belén; Felipe Abrio, Irene; Aguilera López, Andrés (American Society for Microbiology, 2009)Cotranscriptional R-loops are formed in yeast mutants of the THO complex, which functions at the interface between ...
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Artículo
The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage
Lafuente Barquero, Juan; Luke Glaser, Sarah; Graf, Marco; Silva, Sonia; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2017)RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence ...
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Artículo
The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability
González Aguilera, Cristina; Tous Rivera, Cristina; Gómez González, Belén; Huertas Sánchez, Pablo; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Cell Biology, 2008)The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in ...
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Artículo
Transcription-mediated replication hindrance: a major driver of genome instability
Gómez González, Belén; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2019)Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, ...
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Artículo
VID22 counteracts G-quadruplex-induced genome instability
Galati, Elena; Bosio, Maria C.; Novarina, Daniele; Chiara, Matteo; Bernini, Giulia M.; Mozzarelli, Alessandro M.; García Rubio, María Luisa; Gómez González, Belén; Aguilera López, Andrés; Carzaniga, Thomas; Todisco, Marco; Bellini, Tommaso; Nava, Giulia M.; Frige, Gianmaria; Lazzaro, Federico (Oxford University Press, 2021)Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer ...
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Artículo
Yeast Sen1 helicase protects the genome from transcription-associated instability
Mischo, Hannah E.; Gómez González, Belén; Grzechnik, Pawel; García Rondón, Ana; Wei, Wu; Steinmetz, Lars; Aguilera López, Andrés; Proudfoot, Nick J. (Elsevier, 2011-01-06)Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated ...