(Chemical Society, 1994) Barnham, Kevin J.; Djuran, Milos I.; Murdoch, Piedad del Socorro; Sadler, Peter J.; Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
NMR investigations of the kinetics and thermodynamics of the competitive binding of L-methionine (Met), L-histidine (His), and 5′-monophosphates of guanosine (5′-GMP), adenosine (5′-AMP), thymidine (5′-TMP) and cytidine (5′-CMP) to [Pt(dien)Cl]+ (dien = 1,5-diamino-3-azapentane) in aqueous solution show that 5′-GMP selectively displaces S-bound Met, a finding which has implications for DNA platination by anticancer drugs in vivo.
