Artículos (Instituto de Investigaciones Químicas (IIQ) – CIC Cartuja)

URI permanente para esta colecciónhttps://hdl.handle.net/11441/10959

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Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (Ss)-DS-ONJ
(Multidisciplinary Digital Publishing Institute (MDPI), 2022) Gómez Jaramillo, Laura; Cano Cano, Fátima; Sánchez Fernández, Elena Matilde; Ortiz Mellet, Carmen; García Fernández, José Manuel; Alcalá, Martín; Álvarez Gallego, Fabiola; Iturregui, Marta; González Montelongo, M. Carmen; Campos Caro, Antonio; Arroba, Ana I.; Aguilar Diosdado, Manuel; Universidad de Sevilla. Departamento de Química orgánica; Junta de Andalucía; Ministerio de Ciencia, Innovación y Universidades (MICINN). España
Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN) in the early stages of the disease. The authors demonstrate that the glycolipid mimetic (Ss)-DS-ONJ is able to abolish inflammation via the induction of autophagy flux and provokes the inhibition of inflammasome complex in ex vivo and in vitro models, using adult kidney explants from BB rats. The contribution of (Ss)-DS-ONJ to reducing inflammatory events is mediated by the inhibition of classical stress kinase pathways and the blocking of inflammasome complex activation. The (Ss)-DS-ONJ treatment is able to inhibit the epithelial-to-mesenchymal transition (EMT) progression, but only when the IL18 levels are reduced by the treatment. These findings suggest that (Ss)-DS-ONJ could be a novel, and multifactorial treatment for DN.