Química Analítica

URI permanente para esta comunidadhttps://hdl.handle.net/11441/10908

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Examinando Química Analítica por Agencia financiadora "Centre for Environmental and Marine Studies. Portugal"

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    Unravelling biochemical responses in the species Mytilus galloprovincialis exposed to the antineoplastics ifosfamide and cisplatin under different temperature scenarios
    (Elsevier, 2024-09-15) Queirós, Vanessa; Azeiteiro, Ulisses M.; Santos Morcillo, Juan Luis; Alonso Álvarez, Esteban; Soares, Amadeu M.V.M.; Barata, Carlos; Freitas, Rosa; Universidad de Sevilla. Departamento de Química Analítica; Centre for Environmental and Marine Studies. Portugal
    This study investigates the chronic impact of two of the most widely consumed antineoplastic drugs, Ifosfamide (IF) and Cisplatin (CDDP), on the bivalve species Mytilus galloprovincialis under current (17 °C) and predicted warming conditions (21 °C). Accompanying the expected increase in worldwide cancer incidence, antineoplastics detection in the aquatic environment is also expected to rise. Mussels were exposed to varying concentrations of IF (10, 100, 500 ng/L) and CDDP (10, 100, 1000 ng/L) for 28 days. Biochemical analyses focused on metabolic, antioxidant and biotransformation capacities, cellular damage, and neurotoxicity. Results showed temperature-dependent variations in biochemical responses. Metabolic capacity remained stable in mussels exposed to IF, while CDDP exposure increased it at 1000 ng/L for both temperatures. Antioxidant enzyme activities were unaffected by IF, but CDDP activated them, particularly at 21 °C. Biotransformation capacity was unchanged by IF but enhanced by CDDP. Nevertheless, cellular damage occurred at CDDP concentrations above 100 ng/L, regardless of temperature. Integrated biomarker responses highlighted CDDP's greater impact, emphasizing the critical role of temperature in shaping organismal responses and underscoring the complexity of environmental stressor interactions.