Artículos (Microbiología)

URI permanente para esta colecciónhttps://hdl.handle.net/11441/10904

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Detection of high level of co-infection and the emergence of novel SARS CoV-2 delta-omicron and omicron-omicron recombinants in the epidemiological surveillance of Andalusia
(MDPI, 2023) Pérez-Florido, Javier; Casimiro-Soriguer, Carlos S.; Ortuño, Francisco; Fernández-Rueda, José L.; Aguado, Andrea; Lara, María; Lepe Jiménez, José Antonio; Universidad de Sevilla. Instituto de Biomedicina de Sevilla (IBIS); Universidad de Sevilla. Departamento de Microbiología; Ministerio de Ciencia e Innovación de España; Instituto de Salud Carlos III; Consejería de Salud y Familias, Junta de Andalucía
Recombination is an evolutionary strategy to quickly acquire new viral properties inherited from the parental lineages. The systematic survey of the SARS-CoV-2 genome sequences of the Andalusian genomic surveillance strategy has allowed the detection of an unexpectedly high number of co-infections, which constitute the ideal scenario for the emergence of new recombinants. Whole genome sequence of SARS-CoV-2 has been carried out as part of the genomic surveillance programme. Sample sources included the main hospitals in the Andalusia region. In addition to the increase of co-infections and known recombinants, three novel SARS-CoV-2 delta-omicron and omicron-omicron recombinant variants with two break points have been detected. Our observations document an epidemiological scenario in which co-infection and recombination are detected more frequently. Finally, we describe a family case in which co-infection is followed by the detection of a recombinant made from the two co-infecting variants. This increased number of recombinants raises the risk of emergence of recombinant variants with increased transmissibility and pathogenicity

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Examinando Artículos (Microbiología) por Agencia financiadora "Consejería de Salud y Familias, Junta de Andalucía"