NombreRuiz Pérez, José Francisco
DepartamentoBioquímica Vegetal y Biología Molecular
Área de conocimientoBioquímica y Biología Molecular
Categoría profesionalProfesor Titular de Universidad
Correo electrónicoSolicitar
           
  • Nº publicaciones

    14

  • Nº visitas

    1929

  • Nº descargas

    2527


 

Trabajo Fin de Grado
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Herramientas CRISPR-Cas9 y la posible cura de enfermedades genéticas en humanos: el caso de la anemia falciforme.

González Sainz, Julia; Ruiz Pérez, José Francisco (2023)
Con el avance en el conocimiento de las herramientas de edición génica, la posibilidad de producir modificaciones específicas ...
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An End to a Means: How DNA-End Structure Shapes the Double-Strand Break Repair Process

Serrano Benítez, Almudena; Cortés Ledesma, Felipe; Ruiz Pérez, José Francisco (Frontiers Media, 2020)
Endogenously-arising DNA double-strand breaks (DSBs) rarely harbor canonical 5'-phosphate, 3'-hydroxyl moieties at the ...
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Regulation of human Polλ by ATM-mediated phosphorylation during Non-Homologous End Joining

Sastre Moreno, Guillermo; Pryor, John M.; Moreno Oñate, Marta; Herrero Ruiz, Andrés M.; Cortés Ledesma, Felipe; Ruiz Pérez, José Francisco (Elsevier, 2018)
DNA double strand breaks (DSBs) trigger a variety of cellular signaling processes, collectively termed the DNA-damage ...
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Polμ tumor variants decrease the efficiency and accuracy of NHEJ

Sastre Moreno, Guillermo; Pryor, John M.; Díaz Talavera, Alberto; Ruiz Pérez, José Francisco; Ramsden, Dale A.; Blanco, Luis (Oxford University Press, 2017)
The non homologous end-joining (NHEJ) pathway of double-strand break (DSB) repair often requires DNA synthesis to fill the ...
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A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination

Muñoz Galván, Sandra; García Rubio, María Luisa; Ortega Moreno, Pedro; Ruiz Pérez, José Francisco; Jimeno González, Sonia; Pardo, Benjamín; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2017)
Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to ...
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Yeast pol4 promotes tel1-regulated chromosomal translocations

Sastre Moreno, Guillermo; Aguilera López, Andrés; Ruiz Pérez, José Francisco; Pardo, Benjamín; Blanco Dávila, Luis (2013)
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AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants

Ruiz Pérez, José Francisco; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2011)
Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by ...
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Chromosomal translocations caused by either Pol32-dependent or Pol32-independent triparental break-induced replication

Ruiz Pérez, José Francisco; Gómez González, Belén; Aguilera López, Andrés (American Society for Microbiology, 2009)
Double-strand breaks (DSBs) are harmful DNA lesions that can generate chromosomal rearrangements or chromosome losses if ...
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A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis

Juárez, Raquel; Ruiz Pérez, José Francisco; McElhinny, Stephanie A Nick; Ramsden, Dale A.; Blanco, Luis (Oxford University Press, 2006)
Human DNA polymerase mu (Polm) is a family X member that has terminal transferase activity but, in spite of a non-orthodox ...
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Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe

González Barrera, Sergio; Sánchez, Arancha; Ruiz Pérez, José Francisco; Juárez, Raquel; Picher, Ángel J.; Terrados, Gloria; Andrade, Paula; Blanco, Luis (Oxford University Press, 2005)
As predicted by the amino acid sequence, the purified protein coded by Schizosaccharomyces pombe SPAC2F7.06c is a DNA ...
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Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate

Piris, Miguel A.; Sáez Castillo, Ana Isabel; Ruiz Pérez, José Francisco; Blanco Dávila, Luis (2004)
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Are there mutator polymerases?

García Díaz, Miguel; Ruiz Pérez, José Francisco; Juárez, Raquel; Terrados, Gloria; Blanco, Luis (Hindawi Publishing Corporation, 2003)
DNA polymerases are involved in different cellular events, including genome replication and DNA repair. In the last few ...
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Lack of sugar discrimination by human pol requires a single glycine residue

Blanco Dávila, Luis; Ruiz Pérez, José Francisco; García Díaz, Miguel; Juárez, Raquel; Terrados, Gloria; Picher, Ángel J.; González Barrera, Sergio; Fernández de Henestrosa, Antonio R. (2003)
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DNA polymerase λ, a novel DNA repair enzyme in human cells

García Díaz, Miguel; Bebenek, Katarzyna; Sabariegos, Rosario; Domínguez, Orlando; Rodríguez, Josana Renato; Kirchhoff, Tomas; García Palomero, Esther; Picher, Ángel J.; Juárez, Raquel; Ruiz Pérez, José Francisco; Kunkel, Thomas A.; Blanco, Luis (American Society for Biochemistry and Molecular Biology Inc., 2002)
DNA polymerase lambda (pol λ) is a novel family X DNA polymerase that has been suggested to play a role in meiotic ...