idUS - Author profile: Roodveldt, Cintia

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Name	Roodveldt, Cintia
Department	Bioquímica Médica y Biología Molecular e Inmunología
Knowledge area	Bioquímica y Biología Molecular
Professional category	Profesora Titular de Universidad
E-mail	Request

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14
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Publications
PhD Thesis Mecanismos modulatorios de MOK en la regulación de la respuesta inflamatoria de la microglía en ELA Pérez Cabello, Jesús; Pozo Pérez, David; Roodveldt, Cintia (2024) La esclerosis lateral amiotrófica (ELA) es una enfermedad neurodegenerativa actualmente incurable que, en el momento del ...
Article MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type- I IFN responses via Brd4 and is involved in ALS Pérez Cabello, Jesús; Silvera Carrasco, Lucía; Franco, Jaime M.; Capilla González, Vivian; García García, Raquel; Pozo Pérez, David; Roodveldt, Cintia (National Academy of Sciences, 2023) Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease affecting motor neurons and ...
Article Immune signaling kinases in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) García García, Raquel; Martín Herrero, Laura; Blanca Pariente, Laura; Pérez Cabello, Jesús; Roodveldt, Cintia (Multidisciplinary Digital Publishing Institute (MDPI), 2021) Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disorder of motor neurons in adults, with a median ...
Article Distinct responses of human peripheral blood cells to different misfolded protein oligomers Leal Lasarte, Magdalena; Mannini, Benedetta; Chiti, Fabrizio; Vendruscolo, Michele; Dobson, Christopher M.; Roodveldt, Cintia; Pozo Pérez, David (Wiley-Blackwell, 2021) Increasing evidence indicates that peripheral immune cells play a prominent role in neurodegeneration connected to protein ...
PhD Thesis Novel molecular mechanisms and signaling pathways of microglial responses in amyotrophic lateral sclerosis (ALS) Leal Lasarte, María Magdalena; Pozo Pérez, David; Roodveldt, Cintia (2019)
Article Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers Mannini, Benedetta; Vecchi, Giulia; Labrador Garrido, Adahir; Fabre, Bertrand; Pozo Pérez, David; Dobson, Christopher M.; Roodveldt, Cintia (American Chemical Society, 2019) The formation of misfolded protein oligomers during early stages of amyloid aggregation and the activation of neuroinflammatory ...
Article Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic parkinsonism model Villadiego Luque, Francisco Javier; Labrador Garrido, Adahir; Franco, Jaime M.; Leal Lasarte, Magdalena; Genst, Erwin J. de; Dobson, Christopher M.; Pozo Pérez, David; Toledo Aral, Juan José; Roodveldt, Cintia (Wiley, 2018) Neuroinflammation mediated by chronically activated microglia, largely caused by abnormal accumulation of misfolded ...
PhD Thesis Alpha-synuclein and immune system crosstalk in parkinson's disease; therapeutic approaches of its modulation by molecular chaperones Labrador Garrido, Adahir; Roodveldt, Cintia; Pozo Pérez, David (2017) This Doctoral Thesis is focused on the interplay between the immune system and the Parkinson’s related protein alpha-Synuclein. ...
Article Editorial: Molecular chaperones and neurodegeneration Roodveldt, Cintia; Outeiro, Tiago F.; Braun, Félix (Frontiers Media, 2017)
Article Commentary: Immunochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases Johnson, Ian Paul; Roodveldt, Cintia (Frontiers Media, 2017) In case we needed reminding, age-related neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease ...
Article The chaperonin CCT inhibits assembly of α-synuclein amyloid fibrils by a specific, conformation-dependent interaction Sot, Begoña; Rubio Muñoz, Alejandra; Leal Quintero, Ahundrey; Martínez Sabando, Javier; Marcilla, Miguel; Roodveldt, Cintia; Valpuesta, José María (Nature Publishing Group, 2017) The eukaryotic chaperonin CCT (chaperonin containing TCP-1) uses cavities built into its double-ring structure to encapsulate ...
PhD Thesis Esclerosis lateral amiotrófica: investigaciones en el modelo sod1g93a y correlaciones de interés clínico Cejudo Guillén, Marta; Roodveldt, Cintia; Pozo Pérez, David; Caballero Hernández, Diana Elia (2016) La esclerosis lateral amiotrófica (ELA) es una enfermedad neurodegenerativa, incurable y de carácter fatal en un plazo de ...
Article Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation Roodveldt, Cintia; Labrador Garrido, Adahir; González Rey, Elena; Lachaud, Christian; Guilliams, Tim; Fernández Montesinos, Rafael; Benítez Rondan, Alicia; Robledo, Gema; Hmadcha, Abdelkrim; Delgado, Mario; Dobson, Christopher M.; Pozo, D. (PLOS, 2013) In recent years, it has become accepted that α-synuclein (αSyn) has a key role in the microglia-mediated neuroinflammation, ...
Article Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants Roodveldt, Cintia; Labrador Garrido, Adahir; Gonzalez-Rey, Elena; Fernández Montesinos, Rafael; Caro, Marta; Lachaud, Christian; Waudby, Christopher A.; Delgado, Mario; Dobson, Christopher M.; Pozo Pérez, David (Public Library Science, 2010)