idUS - Perfil del autor: Martínez Bailén, Macarena

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Nombre	Martínez Bailén, Macarena
Departamento	Química Orgánica y Farmaceútica
Área de conocimiento	Química Orgánica
Categoría profesional	Profesora Ayudante Doctora
Correo electrónico	Solicitar

Nº publicaciones

7
Nº visitas

319
Nº descargas

287

Tipología

Orden

Publicaciones
Artículo Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease Velueta Viveros, Martha; Martínez Bailén, Macarena; Puerta, Adrián; Romero Hernández, Laura L.; Křen, Vladimír; Merino Montiel, Penélope; Montiel Smith, Sara; Fernandes, Miguel X.; Moreno Vargas, Antonio José; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (Elsevier, 2022) Concerned by the urgent need to explore new approaches for the treatment of Alzheimer's disease, we herein describe the ...
Artículo Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors Franco, Jorge; Piacente, Francesco; Walter, Melanie; Fratta, Simone; Ghanem, Moustafa; Benzi, Andrea; Martínez Bailén, Macarena; Robina Ramírez, Inmaculada; Del Río, Alberto (Multidisciplinary Digital Publishing Institute (MDPI), 2022) NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the ...
Artículo Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars Pingitore, Valeria; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Mészáros, Zuzana; Kulik, Natalia; Slámová, Kristýna; Křen, Vladimír; Bojarová, Pavla; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José (Elsevier, 2022) Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ...
Artículo Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase) Clemente, Francesca; Matassini, Camilla; Giachetti, Sara; Goti, Andrea; Morrone, Amelia; Martínez Bailén, Macarena; Orta, Sara; Merino, Pedro; Cardona, Francesca (American Chemical Society, 2021) We report a straightforward synthetic strategy for the preparation of trihydroxypiperidine azasugars decorated with ...
Artículo Synthesis of “All-Cis” Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors Davighi, Maria Giulia; Clemente, Francesca; Matassini, Camilla; Martínez Bailén, Macarena; Cardona, Francesca; Goti, Andrea (MDPI, 2020) Pharmacological chaperones (PCs) are small compounds able to rescue the activity of mutated lysosomal enzymes when used ...
Artículo Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B Monaco, Serena; Walpole, Samuel; Doukani, Hassan; Nepravishta, Ridvan; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Ramos Soriano, Francisco Javier; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Wiley, 2020) Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ...
Artículo Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars Martínez Bailén, Macarena; Jiménez Ortega, Elena; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Sanz Aparicio, Julia; Talens Perales, David; Polaina, Julio; Matassini, Camilla; Cardona, Francesca; Moreno Vargas, Antonio José (Elsevier, 2019) The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives ...