idUS - Perfil del autor: Martínez Bailén, Macarena

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Nombre	Martínez Bailén, Macarena
Departamento	Química Orgánica y Farmaceútica
Área de conocimiento	Química Orgánica
Categoría profesional	Profesora Ayudante Doctora
Correo electrónico	Solicitar

Nº publicaciones

8
Nº visitas

355
Nº descargas

317

Tipología

Orden

Publicaciones
Artículo Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease Velueta Viveros, Martha; Martínez Bailén, Macarena; Puerta, Adrián; Romero Hernández, Laura L.; Křen, Vladimír; Merino Montiel, Penélope; Montiel Smith, Sara; Fernandes, Miguel X.; Moreno Vargas, Antonio José; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (Elsevier, 2022) Concerned by the urgent need to explore new approaches for the treatment of Alzheimer's disease, we herein describe the ...
Artículo Multivalent glycosystems for human lectins Martínez Bailén, Macarena; Rojo, Javier; Ramos-Soriano, Javier (Royal Society of Chemistry, 2022) Human lectins are involved in a wide variety of biological processes, both physiological and pathological, which have ...
Artículo Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors Franco, Jorge; Piacente, Francesco; Walter, Melanie; Fratta, Simone; Ghanem, Moustafa; Benzi, Andrea; Martínez Bailén, Macarena; Robina Ramírez, Inmaculada; Del Río, Alberto (Multidisciplinary Digital Publishing Institute (MDPI), 2022) NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the ...
Artículo Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars Pingitore, Valeria; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Mészáros, Zuzana; Kulik, Natalia; Slámová, Kristýna; Křen, Vladimír; Bojarová, Pavla; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José (Elsevier, 2022) Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ...
Artículo Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase) Clemente, Francesca; Matassini, Camilla; Giachetti, Sara; Goti, Andrea; Morrone, Amelia; Martínez Bailén, Macarena; Orta, Sara; Merino, Pedro; Cardona, Francesca (American Chemical Society, 2021) We report a straightforward synthetic strategy for the preparation of trihydroxypiperidine azasugars decorated with ...
Artículo Synthesis of “All-Cis” Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors Davighi, Maria Giulia; Clemente, Francesca; Matassini, Camilla; Martínez Bailén, Macarena; Cardona, Francesca; Goti, Andrea (MDPI, 2020) Pharmacological chaperones (PCs) are small compounds able to rescue the activity of mutated lysosomal enzymes when used ...
Artículo Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B Monaco, Serena; Walpole, Samuel; Doukani, Hassan; Nepravishta, Ridvan; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Ramos Soriano, Francisco Javier; Robina Ramírez, Inmaculada; Angulo Álvarez, Jesús (Wiley, 2020) Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ...
Artículo Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars Martínez Bailén, Macarena; Jiménez Ortega, Elena; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Sanz Aparicio, Julia; Talens Perales, David; Polaina, Julio; Matassini, Camilla; Cardona, Francesca; Moreno Vargas, Antonio José (Elsevier, 2019) The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives ...