NameMartínez Reina, Francisco Javier
DepartmentIngeniería Mecánica y Fabricación
Knowledge areaIngeniería Mecánica
Professional categoryCatedrático de Universidad
E-mailRequest
           
  • No. publications

    50

  • No. visits

    5229

  • No. downloads

    8239


 

Master's Final Project
Icon

Diseño de una herramienta computacional para el cálculo del riesgo de fractura osteoporótica basada en un modelo de remodelación ósea.

Gil Gracia, Paula; Martínez Reina, Francisco Javier (2023)
La remodelación ósea es un proceso ejecutado por los huesos que les permite adaptarse a su entorno mecanobiológico, ...
Article
Icon

Spatio-temporal simulations of bone remodelling using a bone cell population model based on cell availability

Calvo Gallego, José Luis; Manchado Morales, Pablo; Pivonka, Peter; Martínez Reina, Francisco Javier (Frontiers, 2023)
Here we developed a spatio-temporal bone remodeling model to simulate the action of Basic Multicelluar Units (BMUs). This ...
Article
Icon

Editorial: Bone integrity in patients with osteoporosis: Evaluation of fracture risk and influence of pharmacological treatments and mechanical aspects

Martínez Reina, Francisco Javier; Pivonka, Peter; Hambli, Ridha (Frontiers Research Foundation, 2023)
Article
Icon

Evolution of relaxation properties of callus tissue during bone transport

Calvo Gallego, José Luis; Mora Macías, Juan; Reina Romo, Esther; Domínguez Abascal, Jaime; Martínez Reina, Francisco Javier (Sage, 2022)
Callus tissue exhibits a viscoelastic behavior that has a strong influence on the distribution of stresses and their ...
Article
Icon

Mechanistic PK-PD model of alendronate treatment of postmenopausal osteoporosis predicts bone site-specific response

Calvo Gallego, José Luis; Pivonka, Peter; Ruiz Lozano, Rocío; Martínez Reina, Francisco Javier (Frontiers Media S.A., 2022)
Alendronate is the most widely used drug for postmenopausal osteoporosis (PMO). It inhibits bone resorption, affecting ...
Article
Icon

Assessment of Strategies for Safe Drug Discontinuation and Transition of Denosumab Treatment in PMO—Insights From a Mechanistic PK/PD Model of Bone Turnover

Martínez Reina, Francisco Javier; Calvo Gallego, José Luis; Martin, Madge; Pivonka, Peter (Frontiers Media S.A., 2022)
Denosumab (Dmab) treatment against postmenopausal osteoporosis (PMO) has proven very efficient in increasing bone mineral ...
Final Degree Project
Icon

Modelo Avanzado de Remodelación Ósea Basado en Agentes. Influencia del TGF- β y del Daño Microestructural

Ranchal Montes, Montserrat; Martínez Reina, Francisco Javier (2022)
La remodelación ósea es un proceso esencial en la vida del hueso, donde éste se encuentra en un bucle de constante formación ...
Article
Icon

The Correlation between Bone Density and Mechanical Variables in Bone Remodelling Models: Insights from a Case Study Corresponding to the Femur of a Healthy Adult

Calvo Gallego, José Luis; Gutiérrez Millán, Fernando; Ojeda Granja, Joaquín; Pérez Ansón, María Ángeles; Martínez Reina, Francisco Javier (MDPI, 2022)
Bone remodelling models (BRM) are often used to estimate the density distribution in bones from the loads they are subjected ...
Master's Final Project
Icon

Implementación en elementos finitos de modelos de remodelación ósea locales y no locales con activación discreta de BMUs

Manchado Morales, Pablo; Martínez Reina, Francisco Javier; Calvo Gallego, José Luis (2021)
La remodelación ósea es un proceso realizado por los huesos para su optimización y reparación. Numerosas enfermedades se ...
Article
Icon

A novel algorithm to resolve lack of convergence and checkerboard instability in bone adaptation simulations using non-local averaging

Calvo Gallego, José Luis; Pivonka, Peter; García Aznar, José Manuel; Martínez Reina, Francisco Javier (Wiley-Blackwell, 2021)
Checkerboard is a typical instability in finite element (FE) simulations of bone adaptation and topology optimization in ...
Article
Icon

Are drug holidays a safe option in treatment of osteoporosis? — Insights from an in silico mechanistic PK–PD model of denosumab treatment of postmenopausal osteoporosis

Martínez Reina, Francisco Javier; Calvo Gallego, José Luis; Pivonka, Peter (Elsevier, 2021)
Recent reviews by the clinical bone research community suggest caution with prescription of drug holidays for patients ...
Article
Icon

Combined Effects of Exercise and Denosumab Treatment on Local Failure in Post-menopausal Osteoporosis–Insights from Bone Remodelling Simulations Accounting for Mineralisation and Damage

Martínez Reina, Francisco Javier; Calvo Gallego, José Luis; Pivonka P. (Frontiers Media S.A., 2021)
Denosumab has been shown to increase bone mineral density (BMD) and reduce the fracture risk in patients with post-menopausal ...
Master's Final Project
Icon

Diseño y entrenamiento de una red neuronal para simular un modelo de remodelación ósea basado en poblaciones celulares

Carrasco Mantis, Ana; Calvo Gallego, José Luis; Martínez Reina, Francisco Javier (2020)
En el siguiente trabajo, se presenta un modelo matemático que trata de simular una de las enfermedades óseas de mayor ...
Article
Icon

Influence of musculotendon geometry variability in muscle forces and hip bone-on-bone forces during walking

Martín-Sosa, Ezequiel; Martínez Reina, Francisco Javier; Mayo Núñez, Juana María; Ojeda Granja, Joaquín (Public Library Science, 2019)
Inverse dynamics problems are usually solved in the analysis of human gait to obtain reaction forces and moments at the ...
Final Degree Project
Icon

Programación de un modelo de remodelación ósea que incorpore la regulación de la homeostasis a nivel intestinal y renal

Labrador Notario, Guillermo; Martínez Reina, Francisco Javier (2019)
El catión calcio (Ca2+) es el responsable de las funciones reguladoras y celulares desempeñadas por el calcio. En su forma ...
Final Degree Project
Icon

Simulación del mieloma múltiple mediante modelos de remodelación ósea basados en poblaciones celulares

Sánchez García, Iratxe; Martínez Reina, Francisco Javier (2019)
En este Trabajo de Fin de Grado vamos a plantear varias simulaciones de la remodelación ósea afectada por el Mieloma ...
Presentation
Icon

Automatic grading of student-specific exercises in large groups of the subject theory of machines and mechanisms

Chamorro Moreno, Rosario; García Vallejo, Daniel; Martínez Reina, Francisco Javier; Reina Romo, Esther (Springer, 2019)
This study establishes an already defined and tested method to grade exercises of kinematics and dynamics within the course ...
Article
Icon

Comparison of the viscoelastic properties of human abdominal and breast adipose tissue and its incidence on breast reconstruction surgery. A pilot study

Calvo Gallego, José Luis; Domínguez Abascal, Jaime; Gómez Cía, Tomás; Ruiz Moya, Alejandro; Gómez Ciriza, G.; Martínez Reina, Francisco Javier (Elsevier, 2019)
Background: Breast cancer is the leading malignant tumor in women in the world. Reconstruction after mastectomy plays a ...
Article
Icon

Effects of long-term treatment of denosumab on bone mineral density: insights from an in-silico model of bone mineralization

Martínez Reina, Francisco Javier; Pivonka, Peter (Elsevier, 2019)
Denosumab is one of the most commonly prescribed anti-resorptive drugs for the treatment of postmenopausal osteoporosis. ...
Master's Final Project
Icon

Implementación de modelos de remodelación ósea basados en poblaciones celulares en un código de elementos finitos

Bordons Carriazo, Laura; Martínez Reina, Francisco Javier (2018)
Se tratará de implementar en el modelo un caso de osteoporosis, en concreto, de osteoporosis postmenopáusica (PMO). Esta ...
Article
Icon

Comparison of the volumetric composition of lamellar bone and the woven bone of calluses

Martínez Reina, Francisco Javier; García Rodríguez, Javier; Mora Macías, Juan; Domínguez Abascal, Jaime; Reina Romo, Esther (SAGE, 2018)
Woven tissue is mainly present in the bone callus, formed very rapidly either after a fracture or in distraction processes. ...
Master's Final Project
Icon

Simulación por Elementos Finitos de la remodelación ósea en el fémur humano. Influencia de la discretización temporal del ciclo de marcha.

Quesada Ortega, Elena; Ojeda Granja, Joaquín; Martínez Reina, Francisco Javier (2018)
La necesidad de conocer como evolucionará el tejido óseo ante alteraciones en las condiciones que lo rodean existe desde ...
Article
Icon

Comparison of different constitutive models to characterize the viscoelastic properties of human abdominal adipose tissue. A pilot study

Calvo Gallego, José Luis; Domínguez Abascal, Jaime; Gómez Cía, Tomás; Gómez Ciriza, G.; Martínez Reina, Francisco Javier (Elsevier, 2018)
Knowing the mechanical properties of human adipose tissue is key to simulate surgeries such as liposuction, mammoplasty ...
Master's Final Project
Icon

Simulación por elementos finitos de la remodelación ósea en el fémur humano. Influencia de la discretización temporal del ciclo de marcha.

Quesada Ortega, Elena; Ojeda Granja, Joaquín; Martínez Reina, Francisco Javier (2018)
La necesidad de conocer como evolucionará el tejido óseo ante alteraciones en las condiciones que lo rodean existe desde ...
Article
Icon

Influence of the Temporomandibular Joint in the Estimation of Bone Density in the Mandible through a Bone Remodelling Model

Commisso Cuñarro, María Soledad; Ojeda Granja, Joaquín; Mayo Núñez, Juana María; Martínez Reina, Francisco Javier (Hindawi, 2018)
The temporomandibular joint (TMJ) plays a key role in the distribution of stresses in the mandible during mastication and ...
PhD Thesis
Icon

Fijación percutánea posterior en lesiones de pelvis en libro abierto. Análisis biomecánico

Serrano Toledano, David; Lázaro Gonzalvez, Ángel; Martínez Reina, Francisco Javier; Giráldez Sánchez, Miguel Ángel (2017)
PhD Thesis
Icon

Experimental characterisation of breast tissues and its application to a numerical model of a healthy breast

Calvo Gallego, José Luis; Martínez Reina, Francisco Javier; Domínguez Abascal, Jaime (2017)
In this work, a great contribution to the knowledge of the biomechanics of the breast has been done. None of the previous ...
Final Degree Project
Icon

Simulación del cáncer de hueso mediante modelos de poblaciones celulares

Carrasco Mantis, Ana; Martínez Reina, Francisco Javier (2017)
La remodelación ósea es un mecanismo de auto-renovación natural del esqueleto de los seres vivos que involucra a un grupo ...
Master's Final Project
Icon

Activación discreta de BMUs en modelos de remodelación ósea interna

Ramírez Solano, Elena; Martínez Reina, Francisco Javier (2017)
En las últimas décadas la ingeniería ha ido tomando un papel de gran importancia en muchos ámbitos médicos. Con recursos ...
Article
Icon

Effect of freezing storage time on the elastic and viscous properties of the porcine TMJ disc

Calvo Gallego, José Luis; Commisso Cuñarro, María Soledad; Domínguez Abascal, Jaime; Tanaka, Eiji; Martínez Reina, Francisco Javier (Elsevier, 2017)
The correct characterisation of the articular disc of the temporomandibular joint (TMJ) is key to study the masticatory ...
Article
Icon

Elastic properties of woven bone: effect of mineral content and collagen fibrils orientation

García Rodríguez, Javier; Martínez Reina, Francisco Javier (Springer, 2017)
Woven bone is a type of tissue that forms mainly during fracture healing or fetal bone development. Its microstructure can ...
Article
Icon

Quasi-Linear Viscoelastic Model of the Articular Disc of the Temporomandibular Joint

Commisso Cuñarro, María Soledad; Calvo Gallego, José Luis; Mayo Núñez, Juana María; Tanaka, Eiji; Martínez Reina, Francisco Javier (Springer, 2016)
A precise characterization of the articular disc of the temporomandibular joint (TMJ) is essential to study the masticatory ...
PhD Thesis
Icon

Lesiones pélvicas tipo APC--II de Young--Burgess: estudio biomecánico de un sistema de fijación con tornillos sacroilíacos y sinfisarios

Anaya Rojas, Manuel; Carranza Bencano, Andrés; Martínez Reina, Francisco Javier; Giráldez Sánchez, Miguel Ángel (2016)
En este estudio se ha evaluado de forma experimental el comportamiento biomecánico de la pelvis tras la simulación de una ...
Article
Icon

The effect of kinematic constraints in the inverse dynamics problem in biomechanics

Ojeda Granja, Joaquín; Martínez Reina, Francisco Javier; Mayo Núñez, Juana María (Springer, 2016)
The inverse dynamics is a classic problem to be solved in gait analysis. The solution is the vector of joint reactions and ...
Article
Icon

Fluid structural analysis of urine flow in a stented ureter

Gómez Blanco, J. Carlos; Martínez Reina, Francisco Javier; Cruz, Domingo; Pagador, J. Blas; Sánchez Margallo, Francisco M.; Soria, Federico;  (Hindawi Publishing Corporation, 2016)
Many urologists are currently studying new designs of ureteral stents to improve the quality of their operations and the ...
Article
Icon

Aplicación de la mecánica de fluidos y la simulación: Tracto urinario y catéteres ureterales

Gómez Blanco, Juan Carlos; Martínez Reina, Francisco Javier; Cruz, Domingo; Pagador, José Blas; Sánchez Margallo, Francisco Miguel; Soria, Federico (INIESTARES S.A., 2016)
The mechanics of urine during its transport from the renal pelvis to the bladder is of great interest for urologists. The ...
Article
Icon

Is cannulated-screw fixation an alternative to plate osteosynthesis in open book fractures? A biomechanical analysis

Lázaro Gonzalvez, Ángel; Martínez Reina, Francisco Javier; Cano Luis, Pedro; Jiménez Baquero, Juan; Sueiro Fernández, José; Giráldez Sánchez, Miguel Ángel (Elsevier, 2016)
Objectives: The current biomechanical work compares the symphyseal and sacroiliac stability obtained with two systems of ...
Final Degree Project
Icon

Modelo de remodelación ósea basado en poblaciones celulares con el efecto de los osteocitos

Bordons Carriazo, Laura; Martínez Reina, Francisco Javier (2016)
Article
Icon

On the Use of Bone Remodelling Models to Estimate the Density Distribution of Bones. Uniqueness of the Solution

Martínez Reina, Francisco Javier; Ojeda Granja, Joaquín; Mayo Núñez, Juana María (Public Library of Science, 2016)
Bone remodelling models are widely used in a phenomenological manner to estimate numerically the distribution of apparent ...
Article
Icon

A polynomial hyperelastic model for the mixture of fat and glandular tissue in female breast

Calvo Gallego, José Luis; Martínez Reina, Francisco Javier; Domínguez Abascal, Jaime (Wiley, 2015)
In the breast of adult women, glandular and fat tissues are intermingled and cannot be clearly distinguished. This work ...
Presentation
Icon

About kinematic consistency in the inverse dynamics problem in biomechanics

Ojeda Granja, Joaquín; Martínez Reina, Francisco Javier; Mayo Núñez, Juana María (2015)
The inverse dynamic analysis is used in the study of the human gait to evaluate the reaction forces transmitted between ...
Article
Icon

Percutaneous iliosacral fixation in external rotational pelvic fractures. A biomechanical analysis

Giráldez Sánchez, Miguel A.; Lázaro Gonzálvez, Ángel; Martínez Reina, Francisco Javier; Serrano Toledano, David; Navarro Robles, Alfredo; Cano Luis, Pedro; Fragkakis, Evangelos M.; Giannoudis, Peter V. (Elsevier, 2015)
Although the gold standard in open book pelvic fractures remains the pubic symphysis (PS) plate fixation, the clinical ...
PhD Thesis
Icon

Modelo de remodelación de callo óseo de fractura de fémur humano

García Rodríguez, Javier; Martínez Reina, Francisco Javier (2014)
El presente trabajo se embarca en la tarea de aplicar los modelos de remodelación ósea con la intención de simular la ...
Article
Icon

A bone remodelling model including the effect of damage on the steering of BMUs

Martínez Reina, Francisco Javier; Reina, I.; Domínguez Abascal, Jaime; García Aznar, J. M. (Elsevier, 2014)
Bone remodelling in cortical bone is performed by the so-called basic multicellular units (BMUs), which produce osteons ...
Article
Icon

A study of the temporomandibular joint during bruxism

Commisso Cuñarro, María Soledad; Martínez Reina, Francisco Javier; Mayo Núñez, Juana María (Nature Publishing Group, 2014)
A finite element model of the temporomandibular joint (TMJ) and the human mandible was fabricated to study the effect of ...
PhD Thesis
Icon

Application of Multibody System Techniques to Human Locomotor System

Ojeda Granja, Joaquín; Martínez Reina, Francisco Javier; Mayo Núñez, Juana María (2012)
PhD Thesis
Icon

Biomechanics of the human mandible including the temporomandibular joint

Commisso Cuñarro, María Soledad; Mayo Núñez, Juana María; Martínez Reina, Francisco Javier (2012)
Article
Icon

Comportamiento viscoelástico cuasi-lineal del disco de la ATM. Parte II: Ensayos experimentales.

Ramiro, C.; Commisso Cuñarro, María Soledad; Martínez Reina, Francisco Javier; Domínguez Abascal, Jaime (Grupo español de fractura, 2011)
En el movimiento de la articulación temporomandibular (ATM), el disco juega un papel muy importante, siendo su función la ...
PhD Thesis
Icon

Aplicación de modelos de remodelación ósea interna al estudio del comportamiento de implantes dentales

Martínez Reina, Francisco Javier; Domínguez Abascal, Jaime; García Aznar, José Manuel (2006)
Que la esperanza de vida aumenta cada día es un hecho evidente, al menos en el mundo desarrollado. En los Estados Unidos, ...
Article
Icon

Numerical estimation of bone density and elastic constants distribution in a human mandible

Martínez Reina, Francisco Javier; García Aznar, José Manuel; Domínguez Abascal, Jaime; Doblaré Castellano, Manuel (Elsevier, 2006)
In this paper, we try to predict the distribution of bone density and elastic constants in a human mandible, based on the ...