Perfil del autor: López López, Óscar
Datos institucionales
Nombre | López López, Óscar |
Departamento | Química Orgánica |
Área de conocimiento | Química Orgánica |
Categoría profesional | Catedrático de Universidad |
Correo electrónico | Solicitar |
Estadísticas
-
Nº publicaciones
43
-
Nº visitas
4653
-
Nº descargas
6375
Publicaciones |
---|
Artículo
Coumarins-lipophilic cations conjugates: Efficient mitocans targeting carbonic anhydrases
(Elsevier, 2024)
Being aware of the need to develop more efficient therapies against cancer, herein we disclose an innovative approach for ... |
Artículo
A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration
(MDPI, 2023)
Neurodegenerative disorders (NDs) include a large range of diseases characterized by neural dysfunction with a multifactorial ... |
Artículo
N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biological Activities against Alzheimer's Disease
(Elsevier, 2023)
The oxindole core is an important structural motif in many natural and synthetic substances with various biological ... |
Artículo
Biotinylated selenocyanates: Potent and selective cytostatic agents
(Elsevier, 2023)
Most of the currently available cytotoxic agents for tackling cancer are devoid of selectivity, thus causing severe ... |
Artículo
Investigation of the Enantioselectivity of Acetylcholinesterase and Butyrylcholinesterase upon Inhibition by Tacrine-iminosugar Heterodimers
(Taylor & Francis, 2023)
The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing ... |
Artículo
Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of ... |
Artículo
Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease
(Elsevier, 2022)
Concerned by the urgent need to explore new approaches for the treatment of Alzheimer's disease, we herein describe the ... |
Patente. Invención
procedimiento para la extracción en hoja de olivo de oleuropeína en una fracción fenólica, composición alimentaria funcional y uso
(Oficina Española de Patentes y Marcas (OEPM)., 2022)
Procedimiento para la extracción en hoja de olivo de oleuropeína en una fracción fenólica, composición alimentaria funcional ... |
Tesis Doctoral
Nuevos tio- y selenoderivados de carbohidratos en enfermedades degenerativas: cáncer y Alzheimer
(2022)
En la presente Tesis Doctoral se han desarrollado nuevas familias de compuestos bioactivos frente a enfermedades complejas ... |
Tesis Doctoral
Nuevos sistemas de reconocimiento molecular basados en organocalcógenos. Agentes antiparasitarios y antiproliferativos
(2022)
La presente Tesis Doctoral, desarrollada en cotutela entre los grupos de investigación Síntesis y Modificación de Productos ... |
Artículo
Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis
(Taylor & Francis, 2022)
Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the ... |
Artículo
Iridium-and Palladium-Based Catalysts in the Pharmaceutical Industry
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Transition metal catalysts play a vital role in a wide range of industrial organic processes. The large-scale production ... |
Artículo
Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the ... |
Artículo
Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
(1) Background: carbonic anhydrases (CAs) are attractive targets for the development of new anticancer therapies; in ... |
Artículo
A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE).
(Taylor and Francis Group, 2022)
The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition wasemployed to connect a ... |
Artículo
A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans
(Royal Society of Chemistry, 2022)
A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) ... |
Artículo
2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases
(Taylor & Francis, 2022)
We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as ... |
Artículo
Tacrine-sugar mimetic conjugates as enhanced cholinesterase inhibitors
(Royal Society of Chemistry, 2021)
We have used the Cu(i)-catalyzed azide-alkyne Huisgen cycloaddition reaction to obtain two families of bivalent heterodimers ... |
Artículo
Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors
(Taylor & Francis Open Access, 2021)
We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. ... |
Artículo
Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
(Taylor & Francis Open Access, 2021)
The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers ... |
Artículo
Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance
(Elsevier, 2021)
Drug resistance remains the major cause of cancer treatment failure especially at the late stage of the disease. However, ... |
Artículo
N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study
(Elsevier, 2020)
Our goal was the evaluation of a series of N-1,2,3-triazole-isatin derivatives for multi-target activity which included ... |
Tesis Doctoral
Síntesis y evaluación de nuevas moléculas multidiana en la prevención de enfermedades degenerativas
(2020)
En la presente Tesis Doctoral se ha llevado a cabo la síntesis y evaluación de nuevos compuestos orgánicos como fármacos ... |
Artículo
Masked Phenolic-Selenium Conjugates: Potent and Selective Antiproliferative Agents Overcoming P-gp Resistance
(MDPI, 2020)
Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number ... |
Artículo
Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease
(American Chemical Society, 2020)
Despite the rapidly increasing number of patients suffering from type 2 diabetes, Alzheimer's disease, and diabetes-induced ... |
Artículo
1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
(American Chemical Society, 2020)
The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide ... |
Artículo
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors
(Elsevier, 2019)
Concerned by the devastating effects of Alzheimer's disease, and the lack of effective drugs, we have carried out the ... |
Artículo
Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations
(Elsevier, 2019)
Herein we report a straightforward preparation of new antiproliferative agents based on the hybridization of a coumarin ... |
Artículo
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells
(MDPI, 2019)
With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new ... |
Artículo
Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs
(Elsevier, 2018)
Herein we report the straightforward preparation of novel conformationally-restricted steroids from trans-androsterone and ... |
Artículo
Debates: An Useful Tool to Promote Students Deeper Thinking in Stem Disciplines
(MDPI AG, 2018)
The utility of debates for the evaluation of a series of transversal competences related to critical thinking is highlighted. ... |
Artículo
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents
(Elsevier, 2017)
We have designed a series of tacrine-based homo- and heterodimers that incorporate an antioxidant tether (selenoureido, ... |
Artículo
Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates
(Royal Society of Chemistry, 2017)
The Michael addition reactions of carbohydrate-derived nitroalkenes with ethyl thioglycolate and 2-mercaptobenzyl alcohol ... |
Patente. Invención
Derivados acilados de carbohidratos, métodos de obtención y usos de los mismos
(Oficina Española de Patentes y Marcas (OEPM), 2016)
Derivados acilados de carbohidratos, métodos de obtención y usos de los mismos. La presente invención describe derivados ... |
Patente. Invención
Derivados acilados de polifenoles y/o carbohidratos, métodos de obtención y usos de los mismos
(Oficina Española de Patentes y Marcas (OEPM), 2016)
Derivados acilados de polifenoles y/o carbohidratos, métodos de obtención y usos de los mismos. La presente invención ... |
Patente. Invención
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
(Oficina Española de Patentes y Marcas (OEPM), 2016)
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación. La presente invención describe cepas microbianas ... |
Patente. Invención
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
(Oficina Española de Patentes y Marcas (OEPM), 2016)
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación. La presente invención describe cepas microbianas ... |
Patente. Invención
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
(Oficina Española de Patentes y Marcas (OEPM), 2016)
Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación. La presente invención describe cepas microbianas ... |
Artículo
A Straightforward Access to New Families of Lipophilic Polyphenols by Using Lipolytic Bacteria
(Public Library of Science, 2016)
The chemical synthesis of new lipophilic polyphenols with improved properties presents technical difficulties. Here we ... |
Patente. Invención
Procedimiento para la obtención de extracto de hidroxitirosol, extracto mezcla de hidroxitirosol y 3,4-dihidroxifenilglicol, y extracto de acetato de hidroxitirosilo, a partir de subproductos del olivo y su purificación
(Oficina Española de Patentes y Marcas (OEPM), 2014)
Procedimiento para la obtención de extracto de hidroxitirosol, extracto mezcla de hidroxitirosol y 3,4- dihidroxifenilglicol, ... |
Tesis Doctoral
Síntesis de nuevos antioxidantes derivados del hidroxitirosol. Interacción con ciclodextrinas
(2014)
En la presente Tesis Doctoral se ha llevado a cabo la preparación de derivados funcionales del hidroxitirosol (HT), con ... |
Artículo
Alkoxyamine-cyanoborane adducts: Efficient cyanoborane transfer agents
(Royal Society of Chemistry, 2011)
We report the synthesis of the hitherto unknown zwitterionic alkoxyamino cyanoboranes by reduction of O-alkyloximes with ... |
Tesis Doctoral
Compuestos organoselénicos derivados de carbohidratos. Isoselenocianatos, selenoureas y selenoheterociclos
(2007)
En esta Tesis Doctoral se ha puesto a punto un procedimiento eficaz de conversión de tioureas derivadas de azúcar en las ... |