Perfil del autor: Fernández-Chacón, Rafael
Datos institucionales
Nombre | Fernández-Chacón, Rafael |
Departamento | Fisiología Médica y Biofísica |
Área de conocimiento | Fisiología |
Categoría profesional | Catedrático de Universidad |
Correo electrónico | Solicitar |
Estadísticas
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Nº publicaciones
19
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Nº visitas
3710
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Nº descargas
5340
Publicaciones |
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Tesis Doctoral
Estudio del papel de CSPa/DNAJC5 en la función y mantenimiento de las sinapsis glutamatérgicas del hipocampo en ratones adultos
(2023)
La cochaperona sináptica Cysteine String Protein CSP /DNAJC5) se ha implicado en la patogénesis de enfermedades ... |
Tesis Doctoral
Single‐cell transcriptomic and functional characterization of cortical parvalbumin interneurons in a novel conditional knock‐out mouse lacking CSPα/DNAJC5
(2019)
Neurodegenerative diseases are progressive disorders currently without cure. Indeed, the molecular mechanisms underlying ... |
Artículo
Substantia nigra dopaminergic neurons and striatalinterneurons are engaged in three parallel but interdependentpostnatal neurotrophic circuits
(Anatomical Society of Great Britain and Ireland, 2018)
The striatum integrates motor behavior using a well‐defined microcircuit whose individual components are independently ... |
Tesis Doctoral
Presynaptic calcium dynamics, neuronal excitability and synaptic vesicle Cycle in central synapses lacking cysteine string protein-alpha (CSP-ALPHA).
(2017)
Cysteine String Protein-α (CSP-α) is a molecular co-chaperone of the synaptic vesicles that prevents presynaptic degeneration. ... |
Artículo
Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
(Public Library of Science, 2016)
One of the most fascinating properties of the brain is the ability to function smoothly across decades of a lifespan. ... |
Artículo
A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss
(Wiley-Blackwell Publishing Ltd., 2016)
Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and ... |
Tesis Doctoral
Identificación de una firma inmunohistoquímica con valor predictivo en el carcinoma infiltrante de mama de tipo no especial (NST)
(2015)
Introducción: En la actualidad, el cáncer de mama es la neoplasia maligna más común en la mujer, siendo la causa principal ... |
Artículo
Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease
(2011)
In Huntington’s disease (HD), the expansion of polyglutamine (polyQ) repeats at the N terminus of the ubiquitous protein ... |
Artículo
Cysteine String Protein- Prevents Activity-Dependent Degeneration in GABAergic Synapses
(2010)
The continuous release of neurotransmitter could be seen to place a persistent burden on presynaptic proteins, one that ... |
Artículo
Deletion of CASK in mice is lethal and impairs synaptic function
(2007)
CASK is an evolutionarily conserved multidomain protein composed of an N-terminal Ca2_/calmodulin-kinase domain, central ... |
Artículo
Monitoring synaptic function at the neuromuscular junction of a mouse expressing synaptopHluorin
(2007)
We monitored presynaptic exocytosis and vesicle recycling at neuromuscular junctions of transgenic mice expressing ... |
Artículo
CSP alpha-deficiency causes massive and rapid photoreceptor degeneration
(2006)
Cysteine string protein (CSP) _ is an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of ... |
Artículo
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration
(CELL PRESS, 2004)
Cysteine string protein α (CSPα)—an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 ... |
Artículo
Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2
(2003)
We tested the long-standing hypothesis that synaptotagmin 1 is the Ca2 +_ sensor for fast neurosecretion by analyzing the ... |
Artículo
Rab3D Is Not Required for Exocrine Exocytosis but for Maintenance of Normally Sized Secretory Granules
(2002)
Rab3D, a member of the Rab3 subfamily of the Rab/ypt GTPases, is expressed on zymogen granules in the pancreas as well as ... |
Artículo
Structure/Function Analysis of Ca2 + Binding to the C2A Domain of Synaptotagmin 1
(2002)
Synaptotagmin 1, a Ca2+ sensor for fast synaptic vesicle exocytosis, contains two C2 domains that form Ca2+ -dependent ... |
Artículo
Novel SCAMPs Lacking NPF Repeats: Ubiquitous and Synaptic Vesicle-Specific Forms Implicate SCAMPs in Multiple Membrane- Trafficking Functions
(2000)
In vertebrates, secretory carrier membrane proteins (SCAMPs) 1–3 constitute a family of putative membrane-trafficking ... |
Artículo
Oxygen sensing by ion channels and chemotransduction in single glomus cells
(1996)
We have monitored cytosolic [Ca2+] and dopamine release in intact fura-2-loaded glomus cells with microfluoroimetry and a ... |
Artículo
Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells
(1994)
We have investigated the changes of cytosolic [Ca2+1 and the secretory -activity in single glomus cells dispersed from ... |