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Artículo
Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers
(American Chemical Society, 2019)
The formation of misfolded protein oligomers during early stages of amyloid aggregation and the activation of neuroinflammatory responses are two key events associated with neurodegenerative diseases. Although it has been ...
Artículo
Tesis Doctoral
Esclerosis lateral amiotrófica: investigaciones en el modelo sod1g93a y correlaciones de interés clínico
(2016-06-03)
La esclerosis lateral amiotrófica (ELA) es una enfermedad neurodegenerativa, incurable y de carácter fatal en un plazo de 3-5 años desde su diagnóstico. Esta enfermedad se caracteriza por la degeneración progresiva de ...
Artículo
MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type- I IFN responses via Brd4 and is involved in ALS
(National Academy of Sciences, 2023)
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease affecting motor neurons and characterized by microglia-mediated neurotoxic inflammation whose underlying mechanisms remain incompletely ...
Tesis Doctoral
Alpha-synuclein and immune system crosstalk in parkinson's disease; therapeutic approaches of its modulation by molecular chaperones
(2017-05-22)
This Doctoral Thesis is focused on the interplay between the immune system and the Parkinson’s related protein alpha-Synuclein. The first part of this work was to study the impact of extracellular aSyn priming on the ...
Artículo
Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic parkinsonism model
(Wiley, 2018)
Neuroinflammation mediated by chronically activated microglia, largely caused by abnormal accumulation of misfolded α-synuclein (αSyn) protein, is known to contribute to the pathophysiology of Parkinson’s disease (PD). In ...
Tesis Doctoral
Tesis Doctoral
Mecanismos modulatorios de MOK en la regulación de la respuesta inflamatoria de la microglía en ELA
(2024-05-13)
La esclerosis lateral amiotrófica (ELA) es una enfermedad neurodegenerativa actualmente incurable que, en el momento del diagnóstico, establece una esperanza de vida de entre 3 y 5 años. Con la evolución de la enfermedad, ...