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Artículo
The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets
(Oxford University Press, 2008)
K-homology (KH) splicing regulator protein (KSRP) is a multi-domain RNA-binding protein that regulates different steps of mRNA metabolism, from mRNA splicing to mRNA decay, interacting with a broad range of RNA sequences. ...
Artículo
Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding
(Nature Research, 2009)
The AU-rich element (ARE)-mediated mRNA-degradation activity of the RNA binding K-homology splicing regulator protein (KSRP) is regulated by phosphorylation of a serine within its N-terminal KH domain (KH1). In the cell, ...