Buscar
Mostrando ítems 1-4 de 4
Artículo
Molecular basis of FIR-mediated c-myc transcriptional control
(Nature Research, 2010)
The far upstream element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, the FBP transcriptional activator binds to the FUSE DNA element upstream of the c-myc promoter. Then, ...
Artículo
Modulation of copper site properties by remote residues determines the stability of plastocyanins
(Elsevier, 2010)
The metal cofactor determines the thermal stability in cupredoxins, but how the redox state of copper modulates their melting points remains unknown. The metal coordination environment is highly conserved in cyanobacterial ...
Artículo
Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets
(Oxford University Press, 2010)
KSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular proliferation and inflammatory response factors. The selectivity of this mRNA degradation ...
Artículo
Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation
(Elsevier, 2010)
Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure and function. Human cytochrome c, with five tyrosine residues, is an excellent case study as it is ...