- idUS
- Listar por autor
Listar por autor "García Fernández, José Manuel"
Mostrando ítems 21-40 de 95
-
Artículo
Cyclodextrin-Based Functional Glyconanomaterials
Rivero Barbarroja, Gonzalo; Benito Hernández, Juan Manuel; Ortiz Mellet, Carmen; García Fernández, José Manuel (MDPI, 2020-12)Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools ...
-
Artículo
Cyclodextrin-based multivalent glycodisplays: Covalent and supramolecular conjugates to assess carbohydrate-protein interactions
Martínez, Álvaro; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry (Great Britain), 2013)Covalent attachment of biorecognizable sugar ligands in several copies at precise positions of cyclomaltooligosaccharide ...
-
Artículo
Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis
Manzanares, Darío; Pérez Carrión, Mª Dolores; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel; Ceña, Valentín (MDPI, 2020)Small interfering ribonucleic acid (siRNA) has the potential to revolutionize therapeutics since it can knockdown very ...
-
Artículo
Cyclodextrin-mediated Crystallization of Acid β-glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues
Brumshtein, Boris; Aguilar Moncayo, Matilde; Benito, Juan Manuel; García Fernández, José Manuel; Silman, Israel; Shaaltiel, Yoseph; Aviezer, David; Sussman, Joel L.; Futerman, Anthony H.; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2011)Cyclodextrin-based host-guest chemistry has been exploited to facilitate co-crystallization of recombinant human acid ...
-
Artículo
Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities
Aguilar Moncayo, Eva M.; Guilloteau, Nicolas; Bienvenu, Céline; Jiménez Blanco, José Luis; Di Giorgio, Christophe; Vierling, Pierre; Benito, Juan M.; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2014)Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining ...
-
Artículo
Deciphering of polycationic carbohydrate based non-viral gene delivery agents by ESI-LTQ-Orbitrap using CID/HCD pairwise tandem mass spectrometry
Przybylsk, Cédric; Benito, Juan M.; Bonnet, Véronique; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2016)For almost three decades, gene therapy has been gaining interest to efficiently treat some severe diseases. In such context, ...
-
Artículo
Differential effects of carbohydrates on arabidopsis pollen germination
Hirsche, Jörg; García Fernández, José Manuel; Stabentheiner, Edith; Großkinsky, Dominik K.; Roitsch, Thomas Georg (Oxford University Press, 2017)Pollen germination as a crucial process in plant development strongly depends on the accessibility of carbon as energy ...
-
Tesis Doctoral
Diseño y síntesis de receptores derivados de carbohidratos: Ciclodextrinas multivalentes, podandos y ciclotrehalinas. Evaluación de su capacidad de complejación y reconocimiento por lectinas
Benito Hernández, Juan Manuel (2001-10-26)Las células presentan en su superficie oligosacáridos ramificados unidos de modo covalente a lípidos (glicolípidos) o ...
-
Artículo
Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells
Gallego-Yerga, Laura; Posadas, Inmaculada; Torre, Cristina de la; Ruiz-Almansa, Jesús; Sansone, Francesco; Ortiz Mellet, Carmen; Casnati, Alessandro; García Fernández, José Manuel; Ceña, Valentín (Frontiers Media, 2017)Giant amphiphiles encompassing a hydrophilic β-cyclodextrin (βCD) component and a hydrophobic calix[4]arene (CA4) module ...
-
Artículo
Dynamic Control of the Self-Assembling Properties of Cyclodextrins by the Interplay of Aromatic and Host-Guest Interactions
Neva, Tania; Carmona, Thais; Benito, Juan M.; Przybylski, Cédric; Ortiz Mellet, Carmen; Mendicuti, Francisco; García Fernández, José Manuel (Frontiers Media, 2019)The presence of a doubly-linked naphthylene clip at the O-2I and O-3II positions in the secondary ring of β-cyclodextrin ...
-
Artículo
Effects of inulin and di-d-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens
Peinado, M.J.; Echávarri, A; Ruiz, R.; Suárez Pereira, E.; Ortiz Mellet, Carmen; García Fernández, José Manuel; Rubio, L. A. (Elsevier, 2013)In vitro and in vivo experiments were designed to evaluate the effectiveness of laboratory-made di-d-fructose dianhydride ...
-
Artículo
Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme
Fuente, Alex de la; Rísquez Cuadro, Rocio; Verdaguer, Xavier; García Fernández, José Manuel; Nanba, Eiji; Higaki, Katsumi; Ortiz Mellet, Carmen; Riera, Antoni (Elsevier, 2016)Due to their capacity to inhibit hexosaminidases, 2-acetamido-1,2-dideoxy-iminosugars have been widely studied as potential ...
-
Artículo
Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycations
Carbajo Gordillo, Ana Isabel; López Fernández, José; Benito, Juan Manuel; Jiménez Blanco, José Luis; Santana Armas, María Luisa; Marcelo, Gema; Ortiz Mellet, Carmen; García Fernández, José Manuel (Wiley, 2022)A robust strategy is reported to build perfectly monodisperse star polycationscombining a trehalose-based cyclooligosaccharide ...
-
Tesis Doctoral
Estrategias de glicosidación con sp2-iminoazúcares. Síntesis de miméticos de manooligosacáridos multivalentes y estudio de sus interacciones con lectinas de tipo-C mediante técnicas espectroscópicas, computacionales y biofísicas
Herrera González, Irene (2022-12-02)Los iminoazúcares, análogos de carbohidratos en los que se ha sustituido el oxígeno endocíclico por un átomo de nitrógeno, ...
-
Artículo
Fluorinated chaperone-ß-cyclodextrin formulations for ß-glucocerebrosidase activity enhancement in neuronopathic Gaucher disease
García Moreno, M. Isabel; Mata, Mario de la; Sánchez Fernández, Elena Matilde; Benito, Juan M.; Díaz Quintana, Antonio Jesús; Fustero, Santos; Nanba, Eiji; Higaki, Katsumi; Sánchez-Alcazar, José Antonio; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2017)Amphiphilic glycomimetics encompassing a rigid, undistortable nor-tropane skeleton based on 1,6-anhydro-L-idonojirimycin ...
-
Artículo
Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties
Padilla Pérez, María del Carmen; Sánchez Fernández, Elena Matilde; González-Bakker, Aday; Puerta, Adrián; Padrón, José M.; Martín-Loro, Francisco; García Fernández, José Manuel; Ortiz Mellet, Carmen (Elsevier, 2023)The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound a very ...
-
Tesis Doctoral
Glicobióticos: desarrollo de caramelos con propiedades funcionales
Atencio Genes, Loyda Esther (2017-07-17)La investigación y la innovación en el terreno de los alimentos funcionales es actualmente un pilar esencial de la industria ...
-
Tesis Doctoral
Glicomiméticos y Glicoligandos anfifílicos. Interacciones con enzimas, receptores y ácidos nucleicos
Rodríguez Lavado, Julio (2015-11-27)En esta Tesis hemos preparado derivados de beta-ciclodextrina, metil alfa-D-glucopiranosa y alfa,alfa’-trehalosa adaptados ...
-
Tesis Doctoral
Glicooligómeros con uniones de tipo pseudoamida y estudio de sus interacciones con fosfato
Bootello Iglesias, Purificación (2007-03-23)Esta Tesis describe el diseño, síntesis y determinación de las propiedades de reconocimiento molecular de una nueva familia ...
-
Tesis Doctoral
Glicoterapias contra el cáncer, la leishmania y enfermedades de depósito lisosomal
Gonçalves Pereira, Rita Alexandra (2016-05-06)