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Artículo
Solving molecular flexible docking problems with metaheuristics: A comparative study
(Elsevier, 2015)
The main objective of the molecular docking problem is to find a conformation between a small molecule (ligand) and a receptor molecule with minimum binding energy. The quality of the docking score depends on two factors: ...
Artículo
Solving Molecular Docking Problems with Multi-Objective Metaheuristics
(MDPI, 2015)
Molecular docking is a hard optimization problem that has been tackled in the past with metaheuristics, demonstrating new and challenging results when looking for one objective: the minimum binding energy. However, only a ...
Artículo
Intelligent OLSR Routing Protocol Optimization for VANETs
(IEEE Computer Society, 2012)
Recent advances in wireless technologies have given rise to the emergence of vehicular ad hoc networks (VANETs). In such networks, the limited coverage ofWiFi and the high mobility of the nodes generate frequent topology ...
Artículo
Intelligent Testing of Traffic Light Programs: Validation in Smart Mobility Scenarios
(Hindawi, 2016)
In smart cities, the use of intelligent automatic techniques to find efficient cycle programs of traffic lights is becoming an innovative front for traffic flow management. However, this automatic programming of traffic ...
Artículo
Multi-objective ligand-protein docking with particle swarm optimizers
(Elsevier, 2019)
In the last years, particle swarm optimizers have emerged as prominent search methods to solve the molecular docking problem. A new approach to address this problem consists in a multi-objective formulation, minimizing the ...
Artículo
Hybrid PSO6 for Hard Continuous Optimization
(Springer, 2015)
In our previous works, we empirically showed that a number of 6±2 informants may endow particle swarm optimization (PSO) with an optimized learning procedure in comparison with other combinations of informants. In this ...
Artículo
Molecular Docking Optimization in the Context of Multi-Drug Resistant and Sensitive EGFR Mutants
(MDPI, 2016)
The human Epidermal Growth Factor (EGFR) plays an important role in signaling pathways, such as cell proliferation and migration. Mutations like G719S, L858R, T790M, G719S/T790M or T790M/L858R can alter its conformation, ...
Artículo
Reducing Vehicle Emissions and Fuel Consumption in the City by Using Particle Swarm Optimization
(Springer, 2015)
Nowadays in current cities the increasing levels of pollution emissions and fuel consumption derived from the road traffic directly affect to the air quality, the economy, and specially the health of citizens. Therefore, ...
Artículo
InDM2: Interactive Dynamic Multi-Objective Decision Making Using Evolutionary Algorithms
(Elsevier, 2018)
Dynamic optimization problems involving two or more conflicting objectives appear in many real-world scenarios, and more cases are expected to appear in the near future with the increasing interest in the analysis ...
Artículo
An ontology-based data integration approach for web analytics in e-commerce
(Elsevier, 2016)
Web analytics has emerged as one of the most important activities in e-commerce, since it allows com- panies and e-merchants to track the behavior of customers when visiting their web sites. There exist aseries of tools ...