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Artículo
Apolar carbohydrates as DNA capping agents
(Royal Society of Chemistry, 2012)
Mono- and disaccharides have been shown to stack on top of DNA duplexes stabilizing sequences with terminal C–G base pairs. Here we present an apolar version of glucose and cellobiose as new capping agents that stack on ...
Artículo
Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents
(Royal Society of Chemistry, 2017)
X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that often requires intravenous administration of contrast agents (CAs) to better visualize soft tissues. In this work, we have ...
Artículo
Synthesis, cell-surface binding, and cellular uptake of fluorescently labeled glucose-DNA conjugates with different carbohydrate presentation
(American Chemical Society, 2010)
Oligonucleotide conjugates carrying carbohydrates at the 5′-end have been prepared. Glucose, fucose, and saccharides containing glucose at the nonreducing end were attached to DNA strands using the classical phosphoramidite ...
Artículo
Highly Polar Carbohydrates Stack Onto DNA Duplexes Via CH/π Interactions
(American Chemical Society, 2011)
Carbohydrate-nucleic acid contacts are known to be a fundamental part of some drug-DNA recognition processes. Most of these interactions occur through the minor groove of DNA, such as in the calicheamicin or anthracycline ...
Artículo
Carbohydrate-DNA interactions at G-quadruplexes: Folding and stability changes by attaching sugars at the 5′-End
(Wiley-Blackwell, 2013)
Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, supramolecular chemistry to nanoscience. We have prepared carbohydrate-DNA conjugates containing the ...
Artículo
Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations
(Springer Nature, 2011)
Oligoribonucleotide conjugates and the corresponding siRNA duplexes against tumor necrosis factor carrying one, two, or four glucose and galactose residues at the 5'-end have been prepared using phosphoramidite chemistry. ...
Artículo
Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates
(Elsevier, 2013)
Oligoribonucleotide conjugates carrying apolar carbohydrates at the 5′-end and the corresponding siRNA duplexes have been prepared using phosphoramidite chemistry. All the carbohydrate-siRNA derivatives were compatible ...