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Artículo
Altered expression of cD300a inhibitory receptor on cD4+ T cells From human immunodeficiency Virus-1-infected Patients: association With Disease Progression Markers
(2018-07-23)
The ability of the CD300a inhibitory receptor to modulate immune cell functions and its involvement in the pathogenesis of many diseases has aroused a great interest in this molecule. Within human CD4+ T lymphocytes from ...
Tesis Doctoral
Epigenética de los procesos de autorrenovación, pluripotencialidad y diferenciación de las células troncales
(2010)
El objetivo general de esta tesis ha sido definir la importancia que poseen los procesos epigenéticos sobre el mantenimiento del estado pluripotente y el proceso de diferenciación de las células troncales embrionarias. ...
Artículo
Artículo
Repeat Instability in the Fragile X-Related Disorders: Lessons from a Mouse Model
(Multidisciplinary Digital Publishing Institute (MDPI), 2019-03-01)
The fragile X-related disorders (FXDs) are a group of clinical conditions that result primarily from an unusual mutation, the expansion of a CGG-repeat tract in exon 1 of the FMR1 gene. Mouse models are proving useful for ...
Artículo
PGC-1alfa controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
(Impact Journals LLC, 2015-04-09)
Due to its role in regulation of mitochondrial function, PGC1α is emerging as an important player in ageing and neurodegenerative disorders. PGC1α exerts its neuroprotective effects by promoting mitochondrial biogenesis ...
Tesis Doctoral
Eficacia de los marcadores bioquímicos para el diagnóstico y pronóstico de la artritis reumatoide en pacientes que acuden a una consulta de atención especializada
(2016-01-29)
La Artritis Reumatoide (AR) es una enfermedad autoinmune sistémica, inflamatoria y crónica que afecta al 0,5-1% de la población. Se asocia a daño articular severo y provoca un grave sufrimiento a la persona que la padece, ...
Artículo
Vasoactive intestinal peptide induces cell cycle arrest and regulatory functions in human T cells at multiple levels
(American Society for Microbiology, 2010-05)
Vasoactive intestinal peptide (VIP) is a potent anti-inflammatory neuropeptide that, by inhibiting Th1-driven responses and inducing the emergence of regulatory T cells (Treg), has been proven successful in the induction ...
Tesis Doctoral
Bases genéticas de la enfermedad de Behçet. Estudio multicéntrico en población española
(2014-12-11)
La enfermedad de Behçet (BD) es una vasculitis sistémica de curso crónico y recidivante cuyos síntomas principales son las aftas orales, ulceras genitales y lesiones oculares. Es una enfermedad de base inmunológica clasificada ...
Artículo
Minor compounds from virgin olive oil attenuate LPS-induced inflammation via visfatin-related gene modulation on primary human monocytes
(Wiley-Blackwell, 2019)
We have analyzed the effects of minor compounds found in the unsaponifiable fraction (UF) and in the phenolic fraction (PF) of virgin olive oil (VOO) on LPS-induced inflammatory response via visfatin modulation in human ...