Listar Ciencias de la Salud por agencia financiadora "European Research Council (ERC)"
Mostrando ítems 1-15 de 15
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Actin nucleators safeguard replication forks by limiting nascent strand degradation
(Oxford University Press, 2023)Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability ...
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ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors
(MDPI, 2022)High-grade glioma, including anaplastic astrocytoma and glioblastoma (GBM) patients, have a poor prognosis due to the lack ...
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Body weight distortions in an auditory-driven body illusion in subclinical and clinical eating disorders
(Nature Research, 2022)Previous studies suggest a stronger influence of visual signals on body image in individuals with eating disorders (EDs) ...
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DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
(Elsevier, 2023)Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic ...
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Exploring multisensory integration of non-naturalistic sounds on body perception in young females with eating disorders symptomatology: a study protocol
(Springer Nature, 2023)Background: Bodily illusions can be used to investigate the experience of being in a body by manipulating the underlying ...
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Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability
(Springer Nature, 2024-05-26)RECQL5 is a member of the conserved RecQ family of DNA helicases involved in the maintenance of genome stability that is ...
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Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q10 Deficiency
(Wiley-Blackwell, 2017-07)Coenzyme Q10 (CoQ10) plays a crucial role in mitochondria as an electron carrier within the mitochondrial respiratory chain ...
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Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
(2018)R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may ...
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Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation
(Frontiers Research Foundation, 2019)Neurogenesis in developing and adult mammalian brain is a tightly regulated process that relies on neural stem cell (NSC) ...
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Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Previously, we reported that MTH1 inhibitors TH588 and TH1579 selectively induce oxidative damage and kill Ras-expressing ...
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Oxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors
(National Academy of Sciences, 2022)Acute oxygen (O2) sensing is essential for adaptation of organisms to hypoxic environments or medical conditions with ...
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Redox signaling in acute oxygen sensing
(Elsevier, 2017-04-26)Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the ...
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The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
(Nature Research, 2023)Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large ...
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Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability
(Elsevier, 2022)DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads ...
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WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage.
(Nature Research, 2022)Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR) causes genomic instability. Genomic ...