Buscar
Mostrando ítems 1-3 de 3
Artículo
Intracellular proton pumps as targets in chemotherapy: V-ATPases and cancer
(Bentham Science Publishers, 2012)
Cancer cells show a metabolic shift that makes them overproduce protons; this has the potential to disturb the cellular acid-base homeostasis. However, these cells show cytoplasmic ...
Artículo
Inorganic pyrophosphatase defects lead to cell cycle arrest and autophagic cell death through NAD+ depletion in fermenting yeast
(Elsevier, 2013)
Inorganic pyrophosphatases are required for anabolism to take place in all living organisms. Defects in genes encoding these hydrolytic enzymes are considered inviable, although their exact nature has not been studied at ...
Artículo
Intraorganellar acidification by V-ATPases: a target in cellproliferation and cancer therapy
(Bentham Science Publishers, 2010)
V-ATPases are multicomponent proton pumps involved in the acidification of singlemembrane intracellular compartments such as endosomes and lysosomes. They couple thehydrolysis of ATP to the translocation of one to two ...