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Artículo
Inorganic Pyrophosphatases: Study of Interest
(Scientific Research Publishing, 2017)
Inorganic pyrophosphatases are enzymes that catalyze the hydrolysis of inorganic pyrophosphate to orthophosphate. These enzymes are divided into two groups: the soluble pyrophosphatases and the membrane pyrophosphatases. ...
Artículo
N-terminal chimaeras with signal sequences enhance the functional expression and alter the subcellular localization of heterologous membrane-bound inorganic pyrophosphatases in yeast
(Portland Press, 2010)
Expression of heterologous multispanning membrane proteins in Saccharomyces cerevisiae is a difficult task. Quite often, the use of multicopy plasmids where the foreign gene is under the control of a strong promoter does ...
Artículo
Intracellular proton pumps as targets in chemotherapy: V-ATPases and cancer
(Bentham Science Publishers, 2012)
Cancer cells show a metabolic shift that makes them overproduce protons; this has the potential to disturb the cellular acid-base homeostasis. However, these cells show cytoplasmic ...
Artículo
Inorganic pyrophosphatase defects lead to cell cycle arrest and autophagic cell death through NAD+ depletion in fermenting yeast
(Elsevier, 2013)
Inorganic pyrophosphatases are required for anabolism to take place in all living organisms. Defects in genes encoding these hydrolytic enzymes are considered inviable, although their exact nature has not been studied at ...
Artículo
Cell stress by phosphate of two protozoa tetrahymena thermophila and tetrahymena pyriformis
(Scientific Research Publishing, 2017)
Phosphorus is one of the bioelements most needed as a compound cell by living organisms. Phosphorus is involved in several pathologies: in human with bone and kidney diseases, in mammals with metabolism disorder (glucose, ...
Artículo
Intraorganellar acidification by V-ATPases: a target in cellproliferation and cancer therapy
(Bentham Science Publishers, 2010)
V-ATPases are multicomponent proton pumps involved in the acidification of singlemembrane intracellular compartments such as endosomes and lysosomes. They couple thehydrolysis of ATP to the translocation of one to two ...